Pharmaceutical Sciences

liles
  • Graduate Student / Research Assistant
Lab Phone: 806-414-9253
E-Mail: taylor.liles@ttuhsc.edu
Mail Address: 1300 S Coulter
Amarillo, TX 79106-1712

Biography

Taylor Liles completed his Bachelor of Science degree in Biology, as well as a Certificate in Neuroscience, from West Texas A&M University, Canyon, Texas, in December 2015. He participated in the Amarillo Biomedical Research Internship (ABRI) with the TTUHSC Graduate School of Biomedical Sciences in summer of 2014. Working with Dr. Abraham Al-Ahmad, Taylor investigated the interactions between the canonical WNT pathway and hypoxia-inducible factor 1 (HIF1) in HeLa cells. The following summer of 2015, he returned to the ABRI program to work in the lab of Dr. Luca Cucullo, investigating the effects of Vornistat on blood-brain barrier efflux transporters such as P-glycoprotein and BCRP. He joined the Graduate Program in Pharmaceutical Sciences as a PhD student in January 2016, and is presently working in the laboratory of Dr. Luca Cucullo with the Department of Pharmaceutical Sciences, continuing his work with Vornistat at the BBB.

Education:

  • BS: Biology, West Texas A&M University, Canyon, Texas, 2015
  • AS: General Science, Amarillo College, Amarillo, Texas, 2013

Research Interests:

Molecular Neuroscience; Pharmacology and Toxicology; BBB modeling

Publications:

  • Prasad S, Sajja RK, Kaisar MA, Park JH, Villalba H, Liles T, Abbruscato T, Cucullo L. Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity. Redox Biol. 2017 Aug;12:58-69.
  • Kaisar MA, Villalba H, Prasad S, Liles T, Sifat AE, Sajja RK, Abbruscato TJ, Cucullo L. Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure? Redox Biol. 2017 Jun 17;13:353-362. 2017 Oct;13:353-362.
  • Kaisar MA, Villalba H, Prasad S, Liles T, Sifat AE, Sajja RK, Abbruscato TJ, Cucullo L. Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure? Redox Biol. 2017 Jun 17;13:353-362.
  • Prasad S, Sajja RK, Kaisar MA, Park JH, Villalba H, Liles T, Abbruscato T, Cucullo L. Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity. Redox Biol. 2017 Feb 12;12:58-69. doi: 10.1016/j.redox.2017.02.007. [Epub ahead of print]
  • Kaisar MA, Sajja RK, Prasad S, Abhyankar VV, Liles T, Cucullo L. New experimental models of the blood-brain barrier for CNS drug discovery. Expert Opin Drug Discov. 2017 Jan;12(1):89-103. Epub 2016 Nov 7.
  • Kaisar MA, Prasad S, Liles T, Cucullo L. A decade of e-cigarettes: Limited research & unresolved safety concerns. Toxicology. 2016 Jul 28;365:67-75. doi: 10.1016/j.tox.2016.07.020. [Epub ahead of print]
  • Cucullo L, Liles T. Membrane Transporters and Pharmacological Implications. J Pharmacovigil. 2016 Jun;4(3). pii: e155. Epub 2016 Jun 8

Presentations:

   Before Admission to GPPS:

  • Taylor Liles, Ravi Sajja, Shikha Prasad, Luca Cucullo. “Vorinostat induces P-glycoprotein activity in Blood-Brain Barrier Endothelium”. Amarillo Biomedical Research Internship (ABRI), TTUHSC, Amarillo, TX; August 2015.
  • Taylor Liles, Abraham Al-Ahmad. “WNT Signaling at the BBB: A potential target for Stroke-Induced Vascular Leakage”. Amarillo Biomedical Research Internship (ABRI), TTUHSC, Amarillo, TX; August 2014.

   After Admission to GPPS:

  • Taylor Liles, Luca Cucullo. "Metformin Attenuates Tobacco and Electronic Cigarette Induced Cerebrovascular Toxicity in Stroke". "Workshop on Neurogenetic Tools: Using Mouse Models to Study Human Neurodegenerative Disease", Jackson Lab, Bar Harbor, ME; April-May 2018.
  • Taylor Liles, Ravi K. Sajja, Shikha Prasad, Peixin Jiang, Luca Cucullo. “Vorinostat Induces Blood-Brain Barrier P-glycoprotein and BCRP Activity: Implications for its Limited use in Combination Chemotherapy.” Fifteenth Annual Research Days, TTUHSC SOP, Amarillo, TX; June 2016.
  • Taylor R. Liles, Ravi K. Sajja, Shikha Prasad, Piexin Jiang, Luca Cucullo. “Vorinostat Induces P-glycoprotein and BCRP Drug Efflux Activity at the Blood-Brain Barrier: Implications for Limited Use in Combination Chemotherapy”. First Annual Meeting of the Center of Excellence for Translational Neuroscience and Therapeutics, TTUHSC, Lubbock, TX; April 2016.

Seminars

  • 02/28/2018 "Behavioral Phenotyping of Cerebral Ischemia in Mice Models"
  • 04/26/2017 "Effects of Vorinostat on Select ABC Transporters at the Blood-Brain Barrier: Implications for Combination Chemotherapy"

Awards/Scholarships:

  • Travel Award, "The Whole Scientist" short course, The Jackson Laboratory, Bar Harbor, Maine; May 2018.
  • Registration Fee Scholarship, NIH, "The Whole Scientist" short course, The Jackson Laboratory, Bar Harbor, Maine; May 2018.
  • Full-Tuition Scholarship, Howard Hughes Medical Institute, “Neurogenetic Tools: Using Mouse Models to Study Human Neurodegenerative Disease" course, The Jackson Laboratory, Bar Harbor, ME; April-May 2018.
  • Full Tuition Scholarship to attend "Principles and Techniques in Mouse Behavioral Phenotyping and Pharmacology Workshop", The Jackson Laboratory, Bar Harbor, ME, October 2017.

Memberships:

  • Society of Collegiate Leadership and Achievement, 2015-present
  • ßßß Biological Honor Society, 2015-present
  • National Society of Leadership and Success – IT Coordinator, 2014-2015
  • National Society of Leadership and Success, 2014-present
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