Pharmaceutical Sciences

suthe
  • Graduate Student / Research Assistant
Lab Phone: 806-414-9229
E-Mail: sreedhar-reddy.suthe@ttuhsc.edu
Mail Address: 1406 S Coulter
Amarillo, TX 79106-1786

Biography

Sreedhar Reddy Suthe completed his Bachelor degree in Pharmacy from Jawaharlal Nehru Technological University, in Hyderabad, India, in 2013. He joined the Graduate Program in Pharmaceutical Sciences as a PhD student in January 2015, and is presently working in the laboratory of Dr. Ming-Hai Wang with the Department of Pharmaceutical Sciences.

Education:

  • BPharm: Jawaharlal Nehru Technological University, Hyderabad, India, 2013

Research Interests:

Cancer Therapeutics; Antibody Drug Conjugates; Drug Discovery and Development; Molecular Cancer Biology.

Publications:

  • Yao HP, Feng L, Weng TH, Hu CY, Suthe SR, Mostofa AGM, Chen LH, Wu ZG, Wang WL, Wang MH. Preclinical Efficacy of Anti-RON Antibody-Drug Conjugate Zt/g4-MMAE for Targeted Therapy of Pancreatic Cancer Overexpressing RON Receptor Tyrosine Kinase. Mol Pharm. 2018 Jun 26. [Epub ahead of print].

Presentations:

   Before Admission to GPPS:

  • Sreedhar Reddy Suthe, Anjali Gupta. "Synthesis and screening of novel substituted 2,3-disubstituted Quinoxaline analogues for Anti-cancer Screening". Patlolla Ramakrishna Reddy College of Pharmacy, Hyderabad, India; March 2013.

   After Admission to GPPS:

  • Sreedhar Reddy Suthe, Hang-Ping Yao, and Ming-Hai Wang. "RON-Targeted Antibody-Drug Conjugate Therapy Ablates Cancer Stem-Like Cells and Induces Long-Term Tumor Regressions in Preclinical Models of Triple-Negative Breast Cancer". Seventeenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2018.
  • Sreedhar Reddy Suthe, Hang-Ping Yao, Paul C. Trippier and Ming-Hai Wang “Development of a novel RON targeted antibody-drug conjugates using cysteine bridging technology for potential treatment of pancreatic cancer”. Experimental Biology / American Society for Biochemistry and Molecular Biology, San Diego, CA; April 2018.
  • PODIUM PRESENTATION: Sreedhar Reddy Suthe, Hang-Ping Yao and Ming-Hai Wang “Reduced RON expression, DM1 resistance and MRP1 upregulation contributes to resistance in colon cancer cells against anti-RON Antibody-drug conjugate Zt/g4-DM1”. Experimental Biology / American Society for Biochemistry and Molecular Biology, San Diego, CA; April 2018.
  • Sreedhar Reddy Suthe, Hang-Ping Yao, Paul C. Trippier and Ming-Hai Wang “Development of a novel RON targeted antibody-drug conjugates using cysteine bridging technology for potential treatment of pancreatic cancer”. American Association for Cancer Research, Chicago, IL; April 2018.
  • Sreedhar Reddy Suthe, Hang-Ping Yao, Paul C. Trippier and Ming-Hai Wang “Development of a novel RON targeted antibody-drug conjugates using cysteine bridging technology for potential treatment of pancreatic cancer”. Society of Toxicology, San Antonio, TX; March 2018.
  • Podium Presentation: Sreedhar Reddy Suthe, Liang Feng, Hang-Ping Yao, Ruiwen Zhang, and Ming-Hai Wang. “A novel antibody-drug conjugate targeting RON-receptor as a therapeutic strategy for treatment of triple-negative breast cancer [TNBC]”. Sixteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo TX; June 2017.
  • Sreedhar Reddy Suthe, Liang Feng, Ming-Hai Wang. “Antibody Drug Conjugates: Opportunities and Challenges.” Fifteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2016.

Seminars:

  • 11/08/2017 "Development of a Novel RON Targeted Antibody-Drug Conjugates using Cysteine Bridging Technology for Potential Treatment of Pancreatic Cancer" [Oral Qualifying Exam, public presentation, counted as Seminar credit]
  • 02/22/2017 A Novel Antibody-Drug Conjugate Targeting RON Receptor-Tyrosine Kinase for Treatment of Triple Negative Breast Cancer (TNBC)”
  • 04/13/2016 "Cysteine Bridging for Stable and Homogeneous Antibody Drug Conjugates(ADC): Synthesis of Bisalkylating Linker"

Awards/Scholarships:

  • Graduate Student Travel Award 2018, American Society for Biochemistry and Molecular Biology ASBMB / Experimental Biology, San Diego, CA; April 2018.
  • Graduate Student Travel Support Award, Society of Toxicology, San Antonio, TX; March 2018.

Memberships:

  • Graduate Student Association at Amarillo, 2015-present
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