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Aging and Alzheimer's Disease Journal Club


In collaboration with School of Medicine Departments, Center of Excellence for Translational Neuroscience and Therapeutics (CTNT) and Texas Tech University - Garrison Institute on Aging (GIA) is starting a journal club titled "Aging and Alzheimer's Disease Journal Club."  

The first meeting will be held on Tuesday, September 29th, 2015 at 12:00 PM in the GIA Conference Room, 4A125.  An agenda for 2015 September - 2016 June will be prepared.  Multiple areas will be covered including, Geriatircs, Aging, Alzheimer's Disease and Obesity/Diabetes.  

The paper which will be discussed by Dr. P. Hemachandra Reddy at the first meeting can be found at the following website:


Journal Club Schedule

Date   Presenter Title
09/29/15   Dr. Hemachandra Reddy Gene regulation and DNA Damage in the Aging Human Brain
11/24/2015   Dr. Josh Lawrence A Novel Nicotinic Mechanism Underlies β-amyloid Induced Neurotoxicity
12/22/2015   Dr. Ramesh Kandimalla Association between Amylin and Amyloid-b Peptides in Plasma in the context of Apolipoprotein E4
01/26/2016   Dr. Subodh Kumar Genome-Wide Serum microRNA Expression Profiling Identifies Serum Biomarkers for Alzheimer's Disease
02/23/2016   Dr. Chandra Sekhar Kuruva Multi-target Drug Discovery for Alzheimer's Disease: Triazinones asBACE-1 and GSK-3b Inhibitors
03/29/2016   Dr. Rui Wang Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
04/26/2016   Dr. Murali Vijayan Selective astrocytic endothelin-1 overexpression contributes to dementia associated ischemic stroke by exaggerating astrocyte-derived amyloid secretion.
05/31/2016   Dr. John Lawrence Accelerated aging of the GABAergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of Alzheimer's Disease
06/28/2016   Dr. Subodh Kumar microRNA-33 Regulates ApoE Lipidation and Amyloid-β_ Metabolism in the Brain
07/26/2016   Dr. Ramesh Kandimalla Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice 
08/30/2016   Linda Yin Meta-Analysis of Peripheral Blood Apolipoprotein E Levels in Alzheimer's Disease
09/27/2016   Dr. Jasvinder Bhatti Time-Restricted Feeding is a Preventative and Therapeutic Intervention Against Diverse Nutritional Challenges
10/25/2016   Dr. Chandra Kuruva Tau-Derived Hexapeptide 306VQIVYK311 Aggregation Inhibitors: Nitrocatechol Moiety as A Pharmacoperone in Drug Design
11/22/2016   Dr. Rui Wang Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model
12/20/2016   Dr. J.A. Pradeepkiran In Silico Modeling of Novel Drug Ligands for Treatment of Concussion Associated Taupathy
01/24/2017   Dr. Jasvinder Bhatti Genetic Analysis of a New Mouse Model for Non-insulin-Dependent Diabetes
02/28/2017   Dr. Chandra Kuruva Determinants of amyloid fibril degradation by the PDZ protease HTRA1
03/28/2017   Dr. Murali Vijayan MicroRNA-103-1 Selectively Downregulates Brain NCX1 and its Inhibition by Anti-miRNA Ameliorates Stroke Damage and Neurological Deficits
04/25/2017   Dr. Maria Manczak Amyloid β-peptides interfere with mitochondrial pre protein import competence by congregation process
05/23/2017   Dr. Hemachandra Reddy Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects Against Adiposity and Insulin Resistance in Mice 
06/27/2017   Dr. Rui Wang Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's Disease
07/25/2017   Jake S. Smith, Dr. Subodh Kumar, Dr. Murali Vijayan Direct Conversion of Normal Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules