Research Projects
The following are some of the GIA's current and recent aging projects and publications.
Research Projects
August 2006 to July 2010 - NIH: "Vascular Inflammation in the Aging Brain." Amount: $1,339,464
December 2005 to September 2007 - McNeil Pharmaceuticals: "Vascular-mediated Neurodegeneration: A Novel Target for Acetaminophen." Amount: $75,000
2006 - McNeil Consumer and Spec Pharmaceuticals: "Vascular-Mediated Neurodegeneration/Alzheimer's: A novel Target for Acetaminophen." Amount $75,000
November 2006 to October 2007 - King Foundation, Cochran County Aging Study, Amount: $58,402
2005 - Texas Department of Aging and Disability Services: "Long Term Care Facility Technology Readiness Program XCFDA." Amount $72,986
2005 - Texas Department of Aging and Disability Services: "Geriatric Education Training Academy." Amount: $48,745.
2005 - Texas Department of Aging and Disability Services/PHS/HRSA: "Long Term Care Demonstration Project 93.778:" Amount: $75,000
2005 - Texas Coordinating Board/Texas Consortium of Alzheimer's/UTMBH: "Texas Consortium of Alzheimer's Disease Centers XCFDA." Amount: $25,000
2005 - NIH/National Institute on Aging: "Cox2-Regulated Testosterone Biosynthesis in Male Aging." Amount: $1,113,750
Publications
Vittal-Rao H, Thirumangakudi L, Desmond P, Grammas P. Cyckin D1, Cdk4 and Bim mediate thrombin-induced apoptosis in cultured cortical neurons. J Neurochem, 10: 498-505, 2007.
Thirumangakudi L, Yin L, Vittal-Rao H, Grammas P. IL-8 induces expression of matrix metalloproteinases, cell cycle and pro-apoptotic proteins, and cell death in cultured neurons. >J Alz Dis,>11:305-311, 2007.
Triapthy D, Thirumangalakudi L, Grammas P. Expression of macrophage inflammatory protein 1-is elevated in Alzheimer’s vessels and is regulated by oxidative stress.:J Alz Dis, : 447-55.
Christov A, Ottman T, Hamdheydari L, Grammas P. Structural changes in Alzheimer’s disease brain microvessels. Submitted
Sanchez A, Chiriva-Internati M, Grammas P. Adeno-associated viral gene transfer of PCAP38 to primary cortical neurons increases neuronal survival in vitro. Submitted
Tripathy D, Sanchez A, Thirumangalakudi L, Grammas P. RANTES upregulation in the Alzheimer’s disease brain: a possible neuroprotective role. Submitted
Abstracts
Tripathy D, Thirumangalakudi L, Grammas P. MIP-1? expression is elevated in Alzheimer’s vessels and is regulated by oxidative and lipid stress. FASEB 2007.
Desmond P, Evola M, Young A, Grammas P. Oxidative stress impairs learning and memory in ApoE knockout mice. FASEB 2007.
Sanchez A, Grammas P. PACAP38 protects against sodium nitroprusside-induced apoptosis in rat cortical neurons. FASEB 2007.
Desmond P, Evola M, Young A, Grammas P. Oxidative stress impairs learning and memory in ApoE knockout mice. TTUHSC Researchers Symposium 2007.
Wall T, Brown G, Grammas P.Oxidative stress and Alzheimer’s disease increase inflammatory protein expression in brain microvessels. TTUHSC Researchers Symposium 2007.