The following are some of the GIA's current and recent aging projects and publications.
December 2005 to September 2007 - McNeil Pharmaceuticals: "Vascular-mediated Neurodegeneration: A Novel Target for Acetaminophen." Amount: $75,000
2006 - McNeil Consumer and Spec Pharmaceuticals: "Vascular-Mediated Neurodegeneration/Alzheimer's: A novel Target for Acetaminophen." Amount $75,000
November 2006 to October 2007 - King Foundation, Cochran County Aging Study, Amount: $58,402
2005 - Texas Department of Aging and Disability Services: "Long Term Care Facility Technology Readiness Program XCFDA." Amount $72,986
2005 - Texas Department of Aging and Disability Services: "Geriatric Education Training Academy." Amount: $48,745.
2005 - Texas Department of Aging and Disability Services/PHS/HRSA: "Long Term Care Demonstration Project 93.778:" Amount: $75,000
2005 - Texas Coordinating Board/Texas Consortium of Alzheimer's/UTMBH: "Texas Consortium of Alzheimer's Disease Centers XCFDA." Amount: $25,000
2005 - NIH/National Institute on Aging: "Cox2-Regulated Testosterone Biosynthesis in Male Aging." Amount: $1,113,750
Vittal-Rao H, Thirumangakudi L, Desmond P, Grammas P. Cyckin D1, Cdk4 and Bim mediate thrombin-induced apoptosis in cultured cortical neurons. J Neurochem, 10: 498-505, 2007.
Thirumangakudi L, Yin L, Vittal-Rao H, Grammas P. IL-8 induces expression of matrix metalloproteinases, cell cycle and pro-apoptotic proteins, and cell death in cultured neurons. >J Alz Dis,>11:305-311, 2007.
Triapthy D, Thirumangalakudi L, Grammas P. Expression of macrophage inflammatory protein 1-is elevated in Alzheimer’s vessels and is regulated by oxidative stress.:J Alz Dis, : 447-55.
Christov A, Ottman T, Hamdheydari L, Grammas P. Structural changes in Alzheimer’s disease brain microvessels. Submitted
Sanchez A, Chiriva-Internati M, Grammas P. Adeno-associated viral gene transfer of PCAP38 to primary cortical neurons increases neuronal survival in vitro. Submitted
Tripathy D, Sanchez A, Thirumangalakudi L, Grammas P. RANTES upregulation in the Alzheimer’s disease brain: a possible neuroprotective role. Submitted
Kruman, II and Schwartz, EI (2008). DNA damage response and neuroprotection. Frontiers in Bioscience [Invited review]. 13:2504-2515.
Schwartz, EI, Smilenov, LB, Price, MA, Osredkar, T, Baker, RA, Ghosh, S, Vollmer, TI., Shi, F-D, Lencinas, A., Stearns, DM., Gorospe, M, and Kruman, II (2007). Cell Cycle Activation in Postmitotic Neurons is essential for DNA Repair. Cell Cycle. 6(3): 318-329.
Kruman II., Mouton, PR, Emokpae, R.,Jr. , Roy G. Cutler RC., and Mattson, MP. (2005). Folate Deficiency Inhibits Proliferation of Adult Hippocampal Progenitors. NeuroReport 16:1055-1059.
Endres M, Ahmadi M, Kruman I, Biniszkiewicz D, Meisel A, Gertz K.(2005). Folate deficiency increases postischemic brain injury. Stroke. 36(2):321-325.
Kruman, I.I. Why Do Neurons Enter the Cell Cycle? (2004). Cell Cycle [Invited review]. 3:769-773.
Kruman, I.I., Wersto, R.P., Cardozo-Pelaez,F., Smilenov, L., Chan, S.L., Chrest, F.J., Emokpae, R.,Jr., Gorospe,M., and Mark P Mattson (2004). Cell cycle activation linked for neuronal cell death induced by DNA damage. Neuron 41:549-561.
Kruman, I.I., Schwartz, E., Kruman, Y. , Cutler, R., Zhu, X., Nigel H. Greig, N.H. , and Mattson, M.P. (2004) Suppression of Uracil-DNA Glycosylase Induces Neuronal Apoptosis. J.Biol.Chem. 279:43952-43960.
Kruman, I.I., Kumaravel, T., Lohani , A. Haughey, N., Pedersen, W., Evans, M., and Mattson, M.P.(2002). Homocysteine and folic acid deficiency enhance A toxicity by DNA repair impairment. Implication in pathogenesis of neurodegeneration J. Neuroscience 22:1752-1762.
Mattson, M.P., Kruman I.I, and Duan,W. (2002). Folic acid and homocysteine in age-related disease. Ageing Res. Rev. 1:95-112.
Duan, W., Ladenheim, B., Cutler, R.G., Kruman, I.I., Cadet, J.L., Mattson, M.P. (2002). Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J Neurochem. 2002. 80:101-10
Turchan, J., Anderson, C., Hauser, K.F., Sun, Q., Zhang, J., Liu, Y., Wise, P.M., Kruman, I., Maragos, W., Mattson, M.P., Booze, R., Nath a. (2001). Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine. BMC Neurosci. 2:3-
Kruman, I.I., Culmsee, C., Chan,S., Kruman,Y., Guo, Z., Penix,L., and Mattson, M.P. (2000). Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J. Neurosci. 20:6920-6926.
Pedersen, W.A., Luo, H., Kruman, I.I., Kasarskis, E.,and Mattson, M.P. (2000) Evidence that the prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis". FASEB J. 14:913-924.
Guo,Z., Kindy, M.S., Kruman, I.I. and Mattson, M.P. (2000) ALS-linked Cu/Zn-SOD mutation impairs cerebral synaptic glucose and glutamate uptake and exacebrates ischemic injury. J. Cereb. Blood Flow Metab 20:463-468.
Kruman, I.I., Pedersen, W., Springer, J.E., and Mattson, M.P. (1999) ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis. Exp. Neurol. 160:28-39.
Kruman, I.I., Nath, A., Maragos, W.F., Chan, S.L., Jones, M., Rangnekar,V.M., Jakel, R. J., and Mattson, M.P. (1999) Evidence that Par-4 participates in pathogenesis of HIV-encephalitis . Am. J. Pathol. 155:39-46.
Kruman I.I., Nath A., Mattson M.P. (1998) HIV protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload and oxidative stress. Exp. Neurol. 154:276-288.
Kruman I.I. and Mattson, M.P. (1999) Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis. J. Neurochem. 72:529-540.
Kruman I.I., Guo Q., Mattson M.P. (1998) Calcium and peroxynitrite mediate staurosporine-induced mitochondrial dysfunction and apoptosis in neural cells. J.Neurosci.Res. 51: 293-308.
Gordon R.Ya., Bocharova L.S., Kruman I.I., Popov V.I., Kazantsev A.P., Khutzian S.S., Karnaukhov,V.N. (1997) Acridin orange as an indicator of ribosome state in a cell. Cytometry. 29:215-221.
Mark, R.J., Keller, J.N., Kruman, I.I., Mattson, M.P. (1997) Basic FGF attenuates amyloid b-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/k+-ATPase activity in hippocampal neurons. Brain Res.736:205-214.
Kruman, I.I., Bruce-Keller, A.J., Bredesen, D, Waeg, G., Mattson, M.P. (1997) Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J. Neurosci. 17:5089-5100.
Tripathy D, Thirumangalakudi L, Grammas P. MIP-1? expression is elevated in Alzheimer’s vessels and is regulated by oxidative and lipid stress. FASEB 2007.
Desmond P, Evola M, Young A, Grammas P. Oxidative stress impairs learning and memory in ApoE knockout mice. FASEB 2007.
Sanchez A, Grammas P. PACAP38 protects against sodium nitroprusside-induced apoptosis in rat cortical neurons. FASEB 2007.
Desmond P, Evola M, Young A, Grammas P. Oxidative stress impairs learning and memory in ApoE knockout mice. TTUHSC Researchers Symposium 2007.
Wall T, Brown G, Grammas P.Oxidative stress and Alzheimer’s disease increase inflammatory protein expression in brain microvessels. TTUHSC Researchers Symposium 2007.