Right now we need your help with these projects:
- Pseudomonas chemotaxis in blood- the effect of thermal injury: (IRB: 13-140) Pseudomonas aeruginosa is a gram negative pathogen that infects acute
wounds such as third degree skin injury. From these infection sites P. aeruginosa
translocates into the bloodstream causing septicemia resulting in a high mortality
rate. While different in vitro and in vivo studies have analyzed the effect of the
environment at different infection sites on P. aeruginosa virulence, little is known
regarding the effect of blood during systemic infection. We hypothesize that human
blood obtained from thermally injured individuals will significantly alter the expression
of P. aeruginosa genes. We are recruiting 20 subjects, age 18-89 years who are admitted
to the Timothy J Harnar Burn Center with thermal injury totaling 20% TBSA or greater.
- The effect of trauma on Pseudomonas aeruginosa gene expression in blood: (IRB: 15-057) Pseudomonas aeruginosa is a gram negative pathogen that infects acute
wounds and translocates into the bloodstream causing septicemia resulting in a high
mortality rate. In previous studies using RNA sequencing analysis, we have found
that P. aeruginosa expressed altered genes when grown in whole blood from injured
patients. However, little is known regarding the effect of blood during systemic
infection. Identifying significantly altered P. aeruginosa genes in patients following
trauma could influence treatment of trauma patients who develop systemic infection.
We are recruiting 32 patients with severe trauma and 32 healthy volunteers. We will
obtain blood samples of about 35 ml from a single blood draw. Healthy volunteers are compensated $25. Currently there is a need for 10 healthy male volunteers and 4 healthy female volunteers.
- RNAsequence Analysis of Microbial Gene Expression in Necrotizing Soft Tissue Infections (IRB: 14-002)
To learn about the causative agents of the skin and soft tissue infections and risk
factors involved in acquiring these infections. While the patient is in the operating
room, small specimens will be taken from the infected tissue.
Admitted to University Medical Center with the diagnosis of skin and soft tissue
18 years of age or older
Be willing to provide tissue samples for RNA sequencing analysis
- Does abnormal neuromuscular junction function play a role in the pathogenesis of motor
fatigue in women with multiple sclerosis? (IRB: L15-098)
$50.00 stipend paid in 2 - $25.00 increments
Multiple Sclerosis (MS) affects more than 2.3 million people worldwide, especially
women of childbearing age. Fatigue is a common complaint in MS. In fact, many MS patients
list fatigue as their worst symptom and as a barrier to employment. The purpose of
this study is to find out if motor fatigue in MS patients is related to problems between
the muscle and nerve. The study will compare 20 women with MS to 10 women without
MS. We hope that this study will lead to better treatment to improve the quality of
life of women with MS.
Inclusion Criteria for MS Group (20 women):
1. Patients with relapsing remitting multiple sclerosis.
2. Age 18 to 65 years
3. Diagnosed with motor fatigue in multiple sclerosis > 6 weeks. Motor fatigue
equates to muscle fatigue due to physical exertion and is alleviated with rest and
associated with fatigability.
4. Has a fatigue severity scale score (FSS) of ≥5 (moderate to severe fatigue).
5. Ambulatory with Expanded Disability Status Scale score (EDSS) 1.5 -6.5.
Inclusion Criteria for Control Group (10 women):
1. Female with no history of multiple sclerosis and no complaint of fatigue
2. Age 18 to 65 years
- Using Behavioral Economics to Achieve Improved Healthy Behavior Outcomes in Breast
Cancer Survivors (IRB: 15-178) The purpose of this study is to find out if daily text messages can
encourage healthy behavior in breast cancer survivors. Healthy habits can help reduce
or prevent obesity. Reducing obesity may lead to a better quality of life for this
group of patients. During this study, participants will receive daily text messages.
Half will receive messages about diet and exercise. The other half will receive neutral
messages about the state of Texas. We will compare the two groups using a behavioral
survey. Blood and urine samples will also be taken for physiological measures.
$50.00 stipend paid in 2- $25.00 increments
Body mass index (BMI): 25-45 kg/m2
Age: 20-75 years old
No current pregnancy or lactation
Was diagnosed with Stage 0-IIIB disease within the past 5 years and completed all
local and systemic therapy (including Herceptin) at least 3 months prior to entry.
Women can be on or off anti-hormone therapy.
Currently sedentary (exercise < 2´/week for 30 minutes at moderate intensity in the
past 6 months)
Ambulatory without assistive devices.
To get more information, or to volunteer, e-mail us at firstname.lastname@example.org or give us a call at 806-543-8994.
(Please leave a message if we do not answer- we might be with another volunteer!)