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Profile for Constantinos Mikelis

Constantinos Mikelis

Constantinos Mikelis

  • Assistant Professor SOP Biomedical Sciences Amarillo
Office Phone: 806-414-9242
Email: constantinos.mikelis@ttuhsc.edu
Mail Address: 1406 S Coulter St, Amarillo Research Building
Amarillo TX 79106

Biography

B.S. Biology (2002), University of Patras, Greece.
M.S. Molecular Pharmacology (2004), University of Patras, Greece.
Ph.D. Molecular Pharmacology (2009), University of Patras, Greece.
Sabbatical Training (2009), German Cancer Research Center (dkfz), Heidelberg, Germany.
Postdoc (2009-2014), Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, MD.

Research Interests

The focus of my lab is in the area of vascular biology. We are interested in the role of endothelial cells (cells lining the inner surface of blood and lymphatic vessels) in physiological functions and in various diseases, including cancer. A special focus of the lab is to study the role of a protein, the small GTPase RhoA, on endothelial physiology in pathological conditions with a therapeutic perspective.

Selected Publications:

  • Doçi, C & Mikelis, Constantinos & Lionakis, M & Molinolo, A & Gutkind, J May (2015) Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma. Cancer research.
  • Mikelis, Constantinos & Simaan, M & Ando, K & Fukuhara, S & Sakurai, A & Amornphimoltham, P & Masedunskas, A & Weigert, R & Chavakis, T & Adams, R & Offermanns, S & Mochizuki, N & Zheng, Y & Gutkind, J April (2015) RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nature communications, 6, 6725.
  • Dillenburg-Pilla, P & Patel, V & Mikelis, Constantinos & Zárate-Bladés, C & Doçi, C & Amornphimoltham, P & Wang, Z & Martin, D & Leelahavanichkul, K & Dorsam, R & Masedunskas, A & Weigert, R & Molinolo, A & Gutkind, J March (2015) SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29, 3, 1056-68.
  • Gan, C & Patel, V & Mikelis, Constantinos & Zain, R & Molinolo, A & Abraham, M & Teo, S & Abdul Rahman, Z & Gutkind, J & Cheong, S October (2014) Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis. Oncotarget, 5, 20, 9626-40.
  • Lionakis, M & Swamydas, M & Fischer, B & Plantinga, T & Johnson, M & Jaeger, M & Green, N & Masedunskas, A & Weigert, R & Mikelis, Constantinos & Wan, W & Lee, C & Lim, J & Rivollier, A & Yang, J & Laird, G & Wheeler, R & Alexander, B & Perfect, J & Gao, J & Kullberg, B & Netea, M & Murphy, P December (2013) CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. The Journal of clinical investigation, 123, 12, 5035-51.
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