TTUHSC Graduate School of Biomedical Sciences
HomeBiomedical SciencesFaculty and Staff

GSBS Faculty Details






Profile for Laurence Wood

Laurence Wood

Laurence Wood

  • Assistant Professor Immunotherapeutics Dept Abi
Office Phone: 325-696-0431
Email: laurence.wood@ttuhsc.edu
Mail Address: 1718 Pine St
Abilene TX 79601-3044

Biography

Dr. Laurence Wood has over a decade of experience working in the development and improvement of therapeutics for breast cancer. During his graduate studies in the Leroy Liu laboratory at Rutgers University, he was part of a research team that discovered a novel mechanism of chemotherapy resistance in breast cancer. This work elucidated a poorly understood inflammatory pathway governing this resistance mechanism, the ISG15 pathway, and its role in breast cancer aggressiveness. His postdoctoral studies under the mentorship of Dr. Yvonne Paterson at the University of Pennsylvania then applied this knowledge to the development of a novel Listeria monocytogenes(Lm)-based immunotherapy that targeted the breast tumor-specific expression of ISG15. This novel therapeutic vaccine was highly effective at reducing metastatic disease in animal models of breast cancer and was subsequently licensed by Advaxis, Inc. for clinical development. In addition to development of novel immunotherapies, Dr. Wood’s work elucidated the mechanisms governing the robust anti-tumor immune responses induced by Lm-based immunotherapies. He continues his research with Lm-based immunotherapies as an Assistant Professor in the Department of Immunotherapeutics and Biotechnology at Texas Tech University Health Sciences Center.

Research Interests

The Wood laboratory is currently focused on two avenues of research. The primary focus of the laboratory is determining the mechanisms by which the ISG15 pathway regulates immunity and tumorigenesis. The second and more translational focus is to advance novel immunotherapies that utilize Listeria monocytogenes-based vectors.

Selected Publications:

  • Villarreal, Daniel & Wise, Megan & Siefert, Rebekah & Yan, Jian & Wood, Laurence & Weiner, David August (2015) Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity. Molecular therapy : the journal of the American Society of Gene Therapy.
  • Sabnani, Manoj & Rajan, Robin & Rowland, Bradley & Mavinkurve, Vikram & Wood, Laurence & Gabizon, Alberto & La-Beck, Ninh February (2015) Liposome promotion of tumor growth is associated with angiogenesis and inhibition of antitumor immune responses. Nanomedicine : nanotechnology, biology, and medicine, 11, 2, 259-62.
  • Wood, Laurence & Paterson, Yvonne May (2014) Attenuated Listeria monocytogenes: a powerful and versatile vector for the future of tumor immunotherapy. Frontiers in cellular and infection microbiology, 4, 51.
  • Guirnalda, Patrick & Wood, Laurence & Goenka, Radhika & Crespo, Joel & Paterson, Yvonne October (2013) Interferon γ-induced intratumoral expression of CXCL9 alters the local distribution of T cells following immunotherapy with Listeria monocytogenes. Oncoimmunology, 2, 8, e25752.
  • Wallecha, Anu & Wood, Laurence & Pan, Zhen-Kun & Maciag, Paulo & Shahabi, Vafa & Paterson, Yvonne January (2013) Listeria monocytogenes-derived listeriolysin O has pathogen-associated molecular pattern-like properties independent of its hemolytic ability. Clinical and vaccine immunology : CVI, 20, 1, 77-84.
©