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Profile for Matt Grisham, PhD

Matt Grisham

Matt Grisham, PhD

  • Chair
Office Phone: 806-743-2598
Mail Address: 3601 4th St Stop 6591
Lubbock TX 79430-6591


Matthew B. Grisham is Professor and Chair of the Department of Immunology and Molecular Microbiology and the Vernon and Elizabeth Chair in Gastroenterology at Texas Tech University Health Sciences Center in Lubbock, Texas. Dr. Grisham graduated from the University of South Florida (USF) in Tampa, Florida with a B.A. degree (with honors) in Biology in 1975. Following graduation, Dr. Grisham enrolled in the graduate program at Texas Tech University Health Sciences Center where he received his PhD. in Biochemistry from the Department of Biochemistry. Dr. Grisham then moved to Memphis, Tennessee where he was awarded a Postdoctoral Fellowship in Immunology and Inflammation at St. Jude Children’s Research Hospital. In 1984, Dr. Grisham was recruited to the University of South Alabama College of Medicine where he assumed the position of Assistant Professor in the Department of Biochemistry. Three years later, he was recruited to the Department of Molecular and Cellular Physiology at LSU Health Sciences Center in Shreveport, Louisiana where he rose through the ranks achieving the position of Professor and Associate Director of the Center of Excellence for Arthritis and Rheumatology. In 2004, Dr. Grisham was awarded the Boyd Professorship from the Louisiana State University Systems Office in Baton Rouge, Louisiana. The Boyd Professorship is awarded in recognition of distinguished scholarship and outstanding contributions to education and represents the highest academic rank that can be bestowed upon a faculty member within the Louisiana State University System. In 20012, Dr. Grisham was recruited to Texas Tech University Health Sciences Center where he assumed the position of Professor and Chair of the Department of Immunology and Molecular Microbiology. Dr. Grisham has received several honors and awards including the Distinguished Alumni Award from Texas Tech University Health Sciences Center, the Intestinal Diseases Research Award from the University of Calgary Health Sciences Center in Calgary, Canada, the William A. Pryor Distinguished Lectureship Award from the Louisiana State University in Baton Rouge and Boyd Professorship. Dr. Grisham has held numerous national and international leadership positions over the past two decades including his service as the President of the Society for Free Radical Biology and Medicine, President of the Gulf Coast Physiological Society, Councilor for the Immunology, Microbiology and Inflammatory Bowel Disease section of the American Gastroenterological Association and Chair of the Gastrointestinal and Liver Section of the American Physiological Society. He has served or is currently serving as an Associate Editor for the journals Free Radical Biology and Medicine; Inflammatory Bowel Diseases, American Journal of Physiology and Journal of Clinical Biochemistry and Nutrition. In addition, he has served or is currently serving on the editorial boards of the Journal of Immunology, Inflammatory Bowel Diseases and the American Journal of Physiology. Dr. Grisham continues to serve as an active member of the Grants Review Committee for the Crohn’s and Colitis Foundation of America for the past 15 years and has served or is currently serving as a member on several different Study Sections/Grant review committees for the National Institutes of Health (NIH). Dr. Grisham’s research focuses on the etiology and treatment of chronic intestinal inflammation. His research has been continuously funded for the past 25 years by the NIH. He has published more than292 peer-reviewed journal articles, 70 book chapters, edited two books and written one book all related to the pathogenesis and regulation of acute and chronic inflammation.

Research Interests

Inflammatory bowel disease; autoimmune diseases; chronic inflammation; cell-based therapy; mucosal immunology

Selected Publications:

  • Koboziev, I & Jones-Hall, Y & Valentine, J & Reinoso Webb, C & Furr, K & Grisham, Matthew July (2015) Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases. Inflammatory bowel diseases, 21, 7, 1652-73.
  • Reinoso, C & Koboziev, I & Furr, K & Phillips, C & Kottapalli, R & Dmitry, O & Jones-Hall, Y & Grisham, Matthew (2014) P-165 Colonization of Lymphopenic Mice with Dysbiotic Microflora Markedly Increases the Severity and Incidence of Chronic Colitis Following T Cell Transfer S95.
  • Jones-Hall, Y & Grisham, M November (2014) Immunopathological characterization of selected mouse models of inflammatory bowel disease: Comparison to human disease. Pathophysiology : the official journal of the International Society for Pathophysiology / ISP, 21, 4, 267-88.
  • Kurmaeva, E & Lord, J & Zhang, S & Bao, J & Kevil, C & Grisham, M & Ostanin, D November (2014) T cell-associated α4β7 but not α4β1 integrin is required for the induction and perpetuation of chronic colitis. Mucosal immunology, 7, 6, 1354-65.
  • Martinez, N & Karlsson, F & Sato, F & Kawai, E & Omura, S & Minagar, A & Grisham, M & Tsunoda, I September (2014) Protective and detrimental roles for regulatory T cells in a viral model for multiple sclerosis. Brain pathology (Zurich, Switzerland), 24, 5, 436-51.