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Profile for Ruth Perez, PhD

Ruth Perez, PhD

  • Associate Professor of Biomedical Sciences
Office Phone: 915-215-4193
Mail Address: 5001 El Paso Dr
El Paso TX 79905-2827



Dr. Ruth Glanville Perez was born in Kansas City Kansas. Her family moved to El Paso TX when she was in the 4th grade. Dr. Perez was educated by the Sisters of Loretto at St. Joseph's Elementary School and Loretto Academy in El Paso. After high school, she obtained a Bachelor's degree in Biological Sciences at the University of Texas at El Paso, earning a minor in Geological Sciences, with Chemistry as her 3rd science. She then earned a master's degree in Experimental Psychology at the University of Texas at El Paso, doing Alzheimer related research in the laboratory of Dr. Donald E. Moss. She then moved with her family to Pittsburgh, PA where she obtained a doctorate in Neurobiology at the Medical School of the University of Pittsburgh. Her postdoctoral studies were conducted in the Department of Neurology at Brigham and Women’s Hospital, of Harvard Medical School in Boston, MA. She then returned to Pittsburgh where she had a faculty appointment and a research laboratory at Allegheny University of the Health Sciences, with joint appointments in Philadephia, PA. She later returned to the University of Pittsburgh School of Medicine in 1999, where she joined the Department of Neurology and conducted research on Alzheimer’s disease and Parkinson’s disease. She also taught in graduate programs and mentored students at the University of Pittsburgh School of Medicine until 2011. In the summer of 2011, Dr. Perez returned to El Paso to join the faculty of the Paul L. Foster School of Medicine and Graduate School of Biomedical Sciences, where she conducts cutting edge translational research and teaches graduate students and medical students.

Research Interests

Dr. Perez studies the normal functions of proteins that aggregate in the brain. This is to better understand how to maintain their normal function and help prevent the brain damage associated with neuroinflammation and neurodegeneration.

Selected Publications:

  • Vidal-Martínez, G & Vargas-Medrano, J & Gil-Tommee, C & Medina, D & Garza, N & Yang, B & Segura-Ulate, I & Dominguez, S & Perez, Ruth September (2016) FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: Contributions of Pro- and Mature-Brain Derived Neurotrophic Factor. The Journal of biological chemistry, 291, 39, 20811 - 20821.
  • Enoru, J & Yang, B & Krishnamachari, S & Villanueva, E & DeMaio, W & Watanyar, A & Chinnasamy, R & Arterburn, J & Perez, Ruth September (2016) Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy. PloS one, 11, 9, e0162162.
  • Benskey, M & Perez, Ruth & Manfredsson, F May (2016) The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease. Journal of neurochemistry, 137, 3, 331-59.
  • Shi, H & Jing, X & Wei, X & Perez, Ruth & Ren, M & Zhang, X & Lou, H January (2015) S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo. Journal of Neurochemistry, 1, 12986, 11.
  • Farrell, Kaitlin & Krishnamachari, Sesha & Villanueva, Ernesto & Lou, Haiyan & Alerte, Tshianda & Peet, Eloise & Drolet, Robert & Perez, Ruth February (2014) Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function Journal of Neurochemistry, 128, 536-546.