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Profile for Souad Sennoune, PhD

Souad Sennoune

Souad Sennoune, PhD

  • Co-director
  • Research Instructor
Office Phone: 806-743-2535
Email: Souad.Sennoune@ttuhsc.edu
Mail Address: MS1021 Mechanical Engineering
Lubbock TX 79409

Research Interests

Our research interest is to demonstrate the significance of vacuolar proton ATPase (V-ATPase) and its relationship to up-regulated glycolysis in cancer cells. In our previous studies, we found that the V-ATPase is up-regulated and translocated in the plasma membrane in metastatic cells, in addition to its normally intracellular compartments localization. From these studies, we addressed the question why the V-ATPase is translocated at the plasma membrane in metastatic cells? We know that glycolysis is extremely sensitive to changes in pH. Importantly, the V-ATPase activity is sensitive to glucose availability. Therefore, we propose that pH acts as the glucose signal via the V-ATPase that responds to changes in intracellular pH and acts as a sensor. The increase in glycolysis leads to intracellular acidification and translocates the V-ATPase at the cell surface to maintain a more alkaline intracellular pH in tumors. For our future studies, the questions to address are: what is the signaling pathway that translocates the V-ATPase at the cell surface? and how V-ATPases is involved in metastasis? Understanding the signaling pathway that translocate the V-ATPase to the cell surface may help to understand cancer and therefore to develop new therapeutic drugs.

Selected Publications:

  • Sennoune, Souad & Martinez-Zaguilan, Raul (2012) Vacuolar H+-ATPase signaling pathway in cancer. Curr. Protein Pept. Sci., 13, 152-163.
  • Pierre, S. & Lesnik, P. & Moreau, M. & Bonello, L & Droy-Lefaix, M & Sennoune, Souad & Duran, M. & Pressley, Thomas & Sampol, J. & Chapman, J. & Maixent, J. (2008) The standardized Ginkgo biloba extract Egb-761 protects vascular endothelium exposed to oxidized low density lipoproteins. Cell Mol Biol, 54, OL1032-1042.
  • ATTAYA, M. & MAITI, D. & Sennoune, Souad & ATTAYA, H. & BAKUNTS, K. & Martinez-Zaguilan, Raul (2004) Endosomes/lysosomes fuse with the plasma membrane and allow insertion of V-ATPase into the plasma membrane and increase in surface area needed for migration. FASEB J, 18, A1023.
  • Duran, M. & Sennoune, Souad & Arnaud, C. & Garcia, S. & Droy-Lefaix, M. & Maixent, J. (2004) Protective effect of the antihypertensive, Cicletanine, on renal function in diabetic spontaneously hypertensive rats. Cell. Mol. Biol., 50, 869-874.
  • CHUA-TUAN, J. & Sennoune, Souad & BAKUNTS, K. & MARTÍNEZ, G. & KEBIR, Y. & Martinez-Zaguilan, Raul (2004) Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential, distribution and functional activity. FASEB J, 18, A188.
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