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Profile for Jim Hutson, PhD

Jim Hutson

Jim Hutson, PhD

  • Associate Vice President for Research
  • Professor
Office Phone: 806-743-3602
Mail Address: 3601 4th St Stop 6252
Lubbock TX 79430-6252

Research Interests

I am interested in the interactions between Leydig cells and macrophages of the testis. We have found that testicular macrophages secrete 25-hydroxycholesterol, an oxysterol that can serve as a substrate for testosterone production by Leydig cells. This oxysterol can also influence the development of Leydig cells and inhibit the actions of LH on Leydig cells in culture. In return, Leydig cells are capable of regulating the number of macrophages in the testis by releasing a mitogen under the regulation of LH and by secreting testosterone that inhibits the production of 25-hydroxycholesterol. The studies presently being conducted in my laboratory are focused on the regulation of 25-hydroxycholesterol in testicular macrophages and the molecular mechanisms through which 25-hydrocholesterol influences Leydig cells.
I am also interested in determining the role of 25-hydroxycholesterol in endometriosis.

Teaching Interests

My present teaching privileges are with first year medical students and graduate students in a dual-listed course called "Biology of Cells and Tissues". My area of teaching expertise is histology.

Selected Publications:

  • Phy, Jennifer & Kulkarni, A & Huang, Jaou-Chen & Hutson, James & Stocco, Douglas & Manna, Pulak (2014) The role of macrophages and xxysterols in endometriosis. Am. Soc. for Reprod. Med..
  • Hutson, James (1994) Testicular Macrophages. Int. Rev. Cytol., 149, 99-143.
  • Hutson, James (1992) Development of digitations between Leydig cells and macrophages Vell Tissue Research, 267, 285-389.
  • Hutson, James (1988) Bactericidal activity of testicular macrophages biology of Reproduction, 38, 830-835.
  • Hutson, James (1988) Leydig cell do not have Fc receptors Journal Andrology, 10, 159-165.