GRANT-ed (Continued)
Potassium Channels
Luis Cuello, PhD, received a four-year renewal grant of $1.2 million from the National Institutes
of Health National Institute of General Medical Sciences for his work, “High-resolution
crystallographic and functional studies of K+ channel function.”
Out of this work, Cuello published a research article, “The Gating Cycle of a K+ Channel at Atomic Resolution,” in the eLIFE research magazine.
Cuello is a permanent member of the NIH Center for Scientific Review Biophysics of Neural Systems Study Section.
“A permanent member of this study section is unheard of,” he said. “I am so happy and proud of this accomplishment.”
Endocannabinoid System
Josee Guindon, PhD, with Daniel Morgan from Pennsylvania State University, received a five-year
$1.5 million grant from the National Institutes of Health National Institute on Drug
Abuse for their study, “Mechanisms of cannabinoid tolerance.”
Stroke Therapy
Vardan T. Karamyan, PhD, along with Thomas Abbruscato, PhD, and Paul Trippier, PhD, received a $2.9 million multiple-principal-investigator grant from the National
Institutes of Health National Institute of Neurological Disorders and Stroke for their
research, “Development and Characterization of Peptidomimetic Small Molecule Activators
of Peptidase Neurolysin (Nln) for Stroke Therapy.”
Stroke is the leading cause of death and long-term disability in the U.S. with an unmet need for effective treatments on a large scale. The researchers plan to develop potent and selective drug like small molecule activators of Nln, which will be sued as research tools and lead chemical entities to move the drug discovery process forward for treatment of human ischemic stroke.
“Stroke affects about 2 percent of the population in the United States and imposes substantial economic burden on the health care system and society in general,” Karamyan said. “Today, we only have one drug used for the treatment of ischemic stroke, and there is an urgent need to develop new therapies for this disorder.”
For more information, read this Daily Dose story.