Raul Martínez-Zaguilán, Ph.D. Publications | Texas Tech University Health Sciences Center

Publications:

  • Reyes A, Chavarria ME, Martinez R. (1983). (Biochemistry of the male genital tract). Gac. Med. Mex. 119: 139-145.
  • Reyes A, Martinez R., Luna M, Chavarria ME, Merino G (1984). Quantitative evaluation of the human spermatozoal motility and acrosome reaction in infertile oligozoospermic men and fertile euspermic men. Arch. Androl. 12: 187-194.
  • Villegas H, Martinez R., Chavarria ME, Reyes A (1987). (Ultrastructural analysis of spermatozoa in euspermic fertile and oligozoospermic infertile men). Ginec. Obstet. Mex. 55: 41-46.
  • Reyes A, Martinez R., Luna M, Chavarria ME (1987). Concentrations of calmodulin in sperm in relation to their motility in fertile euspermic and infertile asthenozoospermic men. Int. J. Androl. 10: 507-515.
  • Martinez R., Gillies RJ, Giuliano KA (1988). Effect of serum on the intracellular pH of BALB/c-3T3 cells: Serum deprivation causes changes in the sensitivity of cells to serum. J. Cell. Physiol. 136: 154-160.
  • Lucas CA, Gillies, RJ, Olson JE, Giuliano KA, Martinez R., Sneider JM (1988). Intracellular acidification inhibits the proliferative response in BALB/c-3T3 cells. J. Cell. Physiol. 136: 161-167.
  • Gillies RJ, Martinez R., Sneider JM, Hoyer PB (1989). Sphingosine inhibits phorbol 12-myristate 13-acetate-, but not serum-induced activation of Na+/H+ exchange in mammalian cells. J. Cell. Physiol. 139: 125-130.
  • Martinez R., Gillies RJ (1989). Dimethylsulfoxide modifies the sensitivity of BALB/c-3T3 cells to the activation of Na+/H+ exchange by phorbol esters. J. Cell. Physiol. 139: 131-135.
  • Gillies RJ, Martínez-Zaguilán R, Martinez GM, Perona R, Serrano R (1990). Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions. Proc. Natl. Acad. Sci. 87: 7414-7418.
  • Reyes A, Martínez-Zaguilán R, Luna M, Chavarria ME (1991). (Biochemistry of the testicular function). In: Selected Topics in Reproductive Biology. Dominguez, R. (ed.), Miguel Angel Porrua Press, p. 195-230.
  • Wegner JA, Martínez-Zaguilán R, Wise ME, Gillies RJ, Hoyer PB (1990). Prostaglandin F2a-induced calcium transients in ovine large luteal cells: I. Alterations of cytosolic-free calcium levels and calcium flux. Endocrinology 127: 3029-3037.
  • Martínez-Zaguilán R, Martinez GM, Lattanzio F, Gillies RJ (1991). Simultaneous measurement of intracellular pH and Ca2+ using the fluorescence of Snarf-1 and Fura-2 in BALB/c-3T3 cells. Am. J. Physiol. (Cell Physiol.) 260:C297-C307.
  • Gillies RJ, Martínez-Zaguilán R (1991). Regulation of intracellular pH in BALB/c-3T3 cells: Bicarbonate raises pH via NaHCO3/HCl exchange and attenuates the activation of Na+/H+ exchange by serum. J. Biol. Chem. 266:1551-1556.
  • Wegner JA, Martínez-Zaguilán R, Gillies RJ, Hoyer PB (1991). Prostaglandin F2alpha-induced calcium transients in ovine large luteal cells: II. Modulation of the transient and resting cytosolic free calcium alters progesterone secretion. Endocrinology, 128: 929-936.
  • García R, Martínez R,. Rábago M, Hernández-Pérez O, Reyes A, Rosado A (1991). Subcellular distribution of phospholipase A2 and ATPases during capacitation and acrosome reaction in guinea pig spermatozoa. Arch. Androl. 26: 93-105.
  • Gillies RJ, Scherer PG, Raghunand N, Okerlund LS, Martínez-Zaguilán R, Hesterberg L, Dale B (1991). Iteration of hybridoma growth and productivity in hollow fiber bioreactors using 31P NMR. Mag. Reson. Med. 18:181-192.
  • Martínez-Zaguilán R, Gillies RJ (1992). A plasma membrane V-type H+-ATPase may contribute to elevated intracellular pH (pHin ) in some human tumor cells. Ann. N.Y.Acad.Sci., 671: 478-480.
  • Martínez-Zaguilán R (1992). Measurement of intracellular Ca2+ and pHin in cultured cells by fluorescence spectroscopy. In: Vitro Methods in Toxicology and Pharmacology. Watson R (ed.). CRC Press, p 217-236.
  • Gillies RJ, Martínez-Zaguilán R, Peterson EP, Perona R (1992). The role of intracellular pH in mammalian cell proliferation. Cell. Physiol. Biochem. 2: 159-179.
  • Martínez-Zaguilán R, Martínez GM, Lynch RM, Gillies RJ (1993). Vacuolar-type H+ ATPase are functionally expressed in plasma membranes of human tumor cells. Am. J. Physiol. (Cell Physiol.) 265: C1015-C1029.
  • Wegner JA, Martínez-Zaguilán R, Gillies RJ, Hoyer PB (1994). Prostaglandin F2alpha releases intracellular calcium from a thapsigargin-sensitive pool in ovine large luteal cells. Am. J. Physiol. (Endocrinol. Metab.) 266:E50-E56.
  • Gunn M, Martínez-Zaguilán R, Walden-Hopkins S, Woolridge D, Gillies RJ (1994). NIH-3T3 cells transfected with a yeast H+-ATPase have altered rates of protein turnover. Arch. Biochem. Biophys. 314:268-275.
  • Sanchez-Armass S, Martínez-Zaguilán R, Martinez GM, Gillies RJ (1994). Regulation of pH in rat brain synaptosomes: Role of bicarbonate and potassium. J. Neurophysiol. 71: 2236-2248.
  • Martínez-Zaguilán R, Gillies RJ, Sanchez-Armass S (1994). Role of Cl- in the regulation of cytosolic pH in rat brain synaptosomes. J. Neurophysiol. 71: 2249-2257.
  • Peterson E, Martínez-Zaguilán R, Martinez GM, Perona R, Gillies RJ (1994). NIH 3T3 cells transfected with a yeast H+-ATPase have altered sensitivity to insulin, IGF-I and PDGF AA. J. Cell Physiol. 159: 551-560.
  • Wysynski A-M, Martínez-Zaguilán R, Alden C, Gandolfi AJ, Gillies RJ (1994). Phenobarbital induces cytosolic acidification in an established liver epithelial cell line. Toxicol. Lett. 74:157-166.
  • Lax D, Martínez-Zaguilán R, Gillies RJ. (1994). Furazolidone increases thapsigargin sensitive Ca2+-ATPase in chick cardiac myocytes. Am. J. Phsyiol. (Heart Circ.Physiol) 267: H734-H741.
  • Martinez GM, Martínez-Zaguilán R, Gillies RJ (1994). Effect of glucose on pHin and [Ca2+]in in NIH-3T3 cells transfected with the yeast P-type-H+-ATPase. J. Cell Physiol. 161:129-141.
  • Martínez-Zaguilán R, Wegner J, Gillies RJ, Hoyer P (1994). Differential regulation of Ca2+ homeostasis in ovine large and small luteal cells. Endocrinology 135: 2099-2108.
  • Martínez-Zaguilán R, Tompkins LS, and Lynch R.M. (1994). Simultaneous analysis of multiple fluorescent probes in single cells by microspectroscopic imaging. Proc. Int. Soc. Optical Engin., S.P.I.E. 2137:17-28.
  • Lien Y-HH, Wang X, Gillies RJ, Martínez-Zaguilán R (1995). Modulation of intracellular free calcium by glucose in madin-darby canine kidney cells: Role of endoplasmic reticulum Ca2+-ATPase. Am. J. Physiol. (Renal Fluid and Electrolyte Physiol) 268: F671-F679.
  • Wang X, Lien Y-HH, Gillies RJ, Martínez-Zaguilán R (1995). Glucose decreases intracellular calcium ([Ca2+]in) and pH (pHin) in cultured rat vascular smooth muscle cells: Role of Ca2+-ATPase. Cell. Physiol. Biochem. 5:299-312.
  • Lien Y-HH, Wang X, Martínez-Zaguilán R (1995). Differential effects of endoplasmic reticulum Ca2+-ATPase inhibitors on Madin Darby Canine Kidney (MDCK) cells. Cell. Physiol. Biochem. 5:371-379.
  • Martínez-Zaguilán R, Seftor EA, Chu Y-W, Hendrix MJC, Gillies RJ (1996). Acidic pH enhances the invasive behavior of human melanoma cells. Clin. Exp. Metastasis. 14:176-186.
  • Martínez-Zaguilán R, Gurule, WM, Lynch RM (1996). Simultaneous measurement of calcium and pH in insulin secreting cell lines by fluorescence spectral imaging. Am. J. Physiol. 270 (Cell Physiol., 39) C1438-C1446.
  • Martínez-Zaguilán R, Parnami, G, Lynch RM. (1996). Selection of fluorescent ion indicators for simultaneous measurements of pH and Ca2+. Cell Calcium. 19:337-349.
  • Martínez-Zaguilán R, Chinnock BF, Wald-Hopkins S, Bernas M, Way D, Witte MH, Gillies RJ (1996). [Ca2+]in and pHin homeostasis in kaposi sarcoma cells. Cell. Physiol.Biochem. 6:169-148.
  • Martínez-Zaguilán R, Wesson DE. (1996). Regulation of endoplasmic reticulum(ER)-Ca2+-ATPase by glycolysis in eukaryotic cells. Min. Electrolyte Metab. 22:318-335.
  • Martínez-Zaguilán R, Tompkins LS, Gillies RJ, Lynch RM (1999). Simultaneous analysis of intracellular pH and Ca2+ from cell populations. Methods Molec.Biol. 114:287-306.
  • Martínez-Zaguilán R, Parnami J, Martinez GM (1998). Mag-Fura-2 (Furaptra) exhibits both low (uM) and high (nM) affinity for Ca2+. Cell. Physiol. Biochem. 8: 158-174.
  • Sarvazyan N, Swift L, Martínez-Zaguilán R (1998). Effect of oxidants on properties of fluorescent calcium indicators. Arch. Biochem. Biophys. 350: 132-136.
  • Martínez-Zaguilán R, Martinez GM, Gomez A, Hendrix MJC, Gillies RJ (1998). Distinct rgulation of pHin and [Ca2+]in in human melanoma cells with different metastatic potential. J. Cell. Physiol. 176: 196-205.
  • Hudson CA, Rojas JS, Sarvazyan N, Wesson DE, Martínez-Zaguilán R (1998). Interactions between benzylamiloride and Fura-2: Studies in vitro and in cardiac myocytes. Arch. Biochem. Biophys. 356: 25-34.
  • Simoni J, Simoni G, Martínez-Zaguilán, R, Wesson d, Lox CD, Prien SD, Kumar V. (1998) Improved blood substitute: Evaluation of its effects on human endothelial cells. ASAIO J 44:M356-M367
  • Rojas JG, Sanka S, Györke S, Wesson DE, Minta A, Martínez-Zaguilán R (1999). Intracellular pH (pHin) and Cytosolic Calcium ([Ca2+]cyt) Regulation via ATPases: Studies in Cell Populations, Single Cells and Subcellular Compartments. Proc.Int.Soc.Optical Engin., S.P.I.E. 3600:000-000
  • Martínez-Zaguilán R. (1999) Angiostantin's partners. Science, 284: 433-434
  • Martínez-Zaguilán R, Raghunand N, Lynch RM, Bellamy W, Martinez GM, Rojas B, Smith D, Dalton WS, Gillies RJ (1999). pH and drug resistance I: Plasmalemmal V-type H+ ATPase is functionally expressed in drug resistant human breast carcinoma cell lines. Biochem. Pharmacol. 57:1037-1046.
  • Raghunand N, Martínez-Zaguilán R, Wright SH, Gillies RJ (1999). pH and drug resistance II: Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs. Biochem. Pharmacol. 57:1037-1046.
  • Meininger CJ, Marinos RS, Hatakeyama K, Martínez-Zaguilán R, Rojas JD, Kelly KA and Wu G (2000). Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetradihydrobiopterine deficiency. Biochem J. 349:353-356.
  • Rojas JG, Sanka SC, Luo D, Martinez GM, and Martínez-Zaguilán R (2000). Proton pumps, angiogenesis and metastatic breast cancer. Proc. Int. Soc. Optical Engin., S.P.I.E., 3924:67-78.
  • Sanka SC, Bennett D, Rojas JR, Tasby G, Meininger CJ, Wu G, Wesson DE, and Martínez-Zaguilán R (2000). Ca2+ homeostasis in microvascular endothelial cells from an insulin-dependent diabetic model: Role of endosomes/lysosomes. Proc. Int. Soc. Optical Engin., S.P.I.E., 3924:56-66.
  • Martinez GM, Gollahon LS, Shafer K, Oomman SK, Busch C, Martinez-Zaguilan R. (2001). Fluorescent pH probes, fluorescent proteins, and intrinsic cellular fluorochromes are tools to study cytosolic pH (pHcyt) in mammalian cells. Proc. Int. Soc. Opt. Engin., SPIE., 4259 :144-156
  • Sanchez-Armass S., Sennoune S., Martinez G.M., Ortega F., Martinez-Zaguilan R. (2002) Cytosolic pH gradients in cultured neuronal cell lines studied by laser scanning confocal microscopy, real time confocal microscopy, and spectral imaging microscopy. Proc. Int. Soc. Opt. Engin., SPIE., 4626:513-522.
  • Sennoune S., Maiti D., Martinez-Zaguilan R. (2003) Analysis of intracellular pH (pHcyt) in mouse models of angiogenesis and carcinogenesis by spectral imaging microscopy, real time confocal imaging and multiphoton spectral imaging. Proc. Int. Soc. Opt. Engin., SPIE., 4967 :135-145
  • Sennoune S., Luo D., Martinez-Zaguilan R. (2004) Plasmalemmal vacuolar-type H+-ATPase in cancer biology. Cell Biochemistry and Biophysics, 40(2) :185-206.
  • Sennoune S, Bakunts K, Martinez GM, Chua-Tuan JL, Kebir Y, Attaya MN, Martinez-Zaguilan R. (2004) Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential, distribution and functional activity. Am. J. Physiol. – Cell Physiol., 286(6) :C1443-1452.
  • Rojas JD, Sennoune S, Martinez GM, Bakunts K, Meinenger CJ, Wu G, Wesson DE, Seftor EA, Hendrix MJC, Martinez-Zaguilan R. (2004) Plasmalemmal vacuolar-type H+-ATPase is decreased in microvascular endothelial cells from a diabetic model. J. Cell Physiol., 201: 190-200.
  • Rojas JD, Sennoune SR, Maiti D, Martinez GM, Bakunts K, Wesson DE, Martinez-Zaguilan R. (2004) Plasmalemmal V-H+-ATPases regulate intracellular pH in human lung microvascular endothelial cells. Biochem. Biophys. Res. Commun., 320: 1123-1132.
  • Martinez-Zaguilan R, Tompkins LS, Gillies RJ, Lynch RM. Simultaneous analysis of intracellular pH and Ca2+ from cell populations. Meth. Mol. Biol, 312: 269-288, 2005.
  • Sanchez-Armass S*, Sennoune SR*, Ortega F, Martinez-Zaguilan R. Spectral imaging microscopy demonstrates cytoplasmic pH oscillations in glial cells. Am. J. Physiol – Cell Physiol, 290(2):C524-538, 2006 (*These authors contributed equally to this work)
  • Shiner EK, Terentyev D, Bryan A, Sennoune S, Martinez-Zaguilan R, Li G, GyörkE S, Williams SW, Rumbaugh KP. Pseudomonas aeruginosa autoinducer modulates host cell responses through calcium signaling. Cellular Microbiology, 2006, in press.
  • Rojas JD*, Sennoune SR*, Maiti D, Bakunts K, Reuveni M, Sanka SC, Martinez GM, Seftor EA, Meininger CJ, Wu G, Wesson DE, Hendrix MJ, Martinez-Zaguilan R. Vacuolar Type H+-ATPases at the plasma membrane regulate pH and cell migration in microvascular endothelial cells. Am. J. Physiol –Heart Circ Physiol, 291: H1147-H1157, 2006 (*These authors contributed equally to this work).
  • Sennoune, SR, Martinez-Zaguilan, R. Plasmalemmal Vacuolar H+-ATPases in Angiogenesis and Cancer. J Bioenerg Biomembr, 39: 427-433, 2007.
  • Hinton, A., Sennoune, S.R., Bond, S., Fang, M., Reuveni, M., Sahagian, G.G., Jay, D., Martinez-Zaguilan, R., Forgac, M. Function of a subunit isoforms of the V-ATPases in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells. J. Biol. Chem., 284: 16400-16408, 2009. 
  • Sennouns, S.R., Martinez-Zaguilan, R. Vacuolar H+-ATPase signaling pathway in cancer. Curr. Protein Pept. Sci., 13:152-163, 2012. 
  • Bastatas, L., Martinez-Marin, D., Mathews, J., Hashem, J., Lee, Y.J., Sennoune, S., Filleur, S., Martinez-Zaguilan, R., Park, S. AFM nano-mechanics and calcium dynamics of prostate cancer cells with distinct metastatic potential. Biochim Biophys Acta 1820:1111-1120, 2012. 
  • Martinez-Zaguilan, R., Tompkins, L.S., Gillies, R.J., Lynch, R.M. Simultaneous analysis of intracellular pH and Ca2+ from cell populations. Methods Mol Biol 937:253-271, 2013. 
  • Helmer, R.A., Martinez-Zaguilan, R., Dertine, J.S., Fulford, C., Foreman, O., Peiris, V., Chilton, S. Helicase-like transcription factor (Hltf) regulates G2/M transition, Wt1/Gata4/Hif-1a cardiac transcription networks, and collagen biogenesis. PLOS One 8:e-80461-80461, 2013. 
  • Sennoune SR, Arutunyan A, del Rosario C, Castro-Marin R, Hussain F, Martínez-Zaguilán R. V-ATPase regulates communication between microvascular endothelial cells and metastatic cells. Cell Mol Biol, 60:19-25, 2014.
  • Cotter K, Cappecci J, Sennoune SR, Huss M, Maier M, Martinez-Zaguilan R, Forgac M. Activity of plasma membrane V-ATPase is critical for the invasion of MD-MB231 breast cancer cells. J Biol Chem 290: 3680-3692, 2015.
  • Manna PR, Sennoune SR, Martinez-Zaguilan R, Slominski AT, and Pruitt K. Regulation of retinoid mediated cholesterol efflux involves liver X receptor activation in mouse macrophages. Biochem Biophys Res Commun 464: 312-317, 2015.
  • Su S, Wang J, Wei J, Martinez-Zaguilan R, Qiu J, Wang S. Efficient phototermal therapy of brain cancer through porphyrin functionalized graphene oxide. New J Chem39: 5743-5749, 2015.
  • Nie S, Zhang J, Martinez-Zaguilan R, Sennoune S, Hossen MN, Lichtenstein AH, Cao J, Meyerrose GE, Paone R, Soontrapa S, Fan Z, Wang S. Detection of atherosclerotic lesions and intimal macrophages using CD36-targeted nanovesicles. J Control Release. 220 (Pt A):61-70, 2015.
  • Sennoune SR, Santos JM, Hussain F, Martínez-Zaguilán R. Sodium calcium exchanger operates in the reverse mode in metastatic human melanoma cells. Cell Mol Biol  61(7):40-49, 2015.
  • Zhang J, Nie S, Martinez-Zaguilan R, Sennoune S, Wang S. Formulation, Characteristics and Anti-atherogenic Bioactivities of CD36-Targeted Epigallocatechin Gallate (EGCG)-Loaded Nanoparticles. Journal of Nutritional Biochemistry. 30:14-23, 2016.
  • Santos, JM, Martínez-Zaguilán R, Facanha AR, Hussain F, Sennoune SR (2016) Vacuolar H+-ATPase in the nuclear membranes regulates nucleo-cytosolic proton gradients. Am J Physiol, Cell Physiol 311:C547-C558.
  • Martínez-Zaguilán R and Sennoune SR. Vacuolar H+-ATPase Signaling in Cancer. Chapter In “Regulation of Ca2+-ATPases, V-ATPases and F-ATPases”, edited by Sajal Chakraborti and Naranjan S. Dhalla, “Advances in Biochemistry in Health and Disease” Springer International Publishing Switzerland, pp. 371- 392, 2016.
  • Su, S, Wang J, Vargas E,Weil J, Martinez-Zaguilan R, Sennoune SR, Pantoya ML, Wang S, Chaudhuri J, Qiu J (2016). Porphyrin immobilized nanographene oxide for enhanced and targeted photothermal therapy of brain cancer. ACS Biomaterials, Sciences & Engineering, 2: 1357-1366.