Profile for Vardan Karamyan, PhD

Vardan Karamyan

Vardan Karamyan, PhD

  • Associate Professor Pharmaceutical Sci Amarillo
Office Phone: 806-414-9239
Mail Address: 1300 S Coulter St
Amarillo TX 79106-1712


Dr. Karamyan joined the Department of Pharmaceutical Sciences in August 2008. He received his Doctor of Pharmacy (Magna cum laude) from the Faculty of Pharmacy, Yerevan State Medical University, Armenia, and Ph.D. in Biology from the Institute of Biochemistry, National Academy of Sciences, Yerevan, Armenia. He continued his postdoctoral training in the laboratory of Dr. Robert C. Speth at the Department of Pharmacology in the School of Pharmacy, University of Mississippi.

Research Interests

Currently, my laboratory focuses on two main research projects: 1) we are studying the (patho)physiological function of peptidase neurolysin (EC in ischemic stroke and other neurological disorders. This project falls under a larger area of our research interests which focus on understanding of the role of brain peptidergic systems in response of brain to injury and adaptation to stress; 2) pharmacological modulation of brain repair and functional recovery after stroke.

Selected Publications:

  • Yang L, Islam MR, Karamyan VT, Abbruscato TJ. In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment.. Brain Research 2015;1609:1-11.
  • Koganti S, Snyder R, Gumaste U, Karamyan VT, Thekkumkara TJ. 2-methoxyestradiol binding of GPR30 down-regulates angiotensin AT(1) receptor.. Eur J Pharmacol 2014;723:131-40.
  • Speth RC, Eduardo CJ, C. B, A. L, L. G, J. SD, K. SL, Ines S, Michael B, Karamyan VT. Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1, isoleucine8 angiotensin II in neurolysin knockout mouse brains. PlosOne 2014;9(8):e105762.
  • Rashid M, Wangler NJ, Yang L, Shah K, Arumugam TV, Abbruscao TJ, Karamyan VT. Functional upregulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain. J Neurochemistry 2014;129(1):179-89.
  • Wangler NJ, Santos KL, Schadock I, Hagen FK, Escher E, Bader M, Speth RC, Karamyan VT. Identification of membrane-bound variant of metalloendopeptidase neurolysin (EC as the non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site. J Biol Chem 2012;287(1):114-22.