Guillermo Altenberg, MD, Ph.D.
Chair of Cell Physiology and Molecular Biophysics
Department of Cell Physiology and Molecular Biophysics
Texas Tech University Health Sciences Center
3601 4th Street, STOP 6551
Lubbock, Texas 79430
Phone: (806) 743-2531
FAX: (806) 743-1512
My laboratory is interested in the mechanisms of transport across biological membranes and in the development of new nanodiscs-based technologies for medical and biotechnology applications. Our main target proteins are connexins, the gap-junction-forming proteins, and multidrug-resistance proteins of the ATP-binding cassette (ABC) superfamily, which export a number of chemically dissimilar compounds from the cells. Connexins are essential for cell-to-cell electrical and chemical communication, and are involved in development, as well as in physiological and pathophysiological processes. Expression of multidrug-resistance proteins such as P-glycoprotein (MDR1) confers resistance to chemotherapeutic agents in cancer cells.
Full list of publications available in PubMed.
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