Murali Vijayan | Texas Tech University Health Sciences Center

Murali Vijayan

Murali Vijayan

Murali Vijayan

Research Assistant Professor

 

Murali Vijayan received his doctoral degree from Bharathidasan University, Tiruchirappalli, Tamil Nadu, India, in 2015. During his Ph.D. study, he investigated the candidate genes and risk of ischemic stroke in south Indians. He joined Dr. Reddy’s laboratory at Texas Tech University Health Sciences Center in November 2015 as a postdoctoral research associate. His postdoctoral study focused on the circulatory microRNAs (miRNAs) as biomarkers and therapeutic targets for ischemic stroke.

He is also involved in several other research projects including characterization of Alzheimer’s disease mouse models - APP (Tg2576 line) and Tau (P301L) and also genetic crossings of APP and Tau mice with voltage-dependent anion channel 1 heterozygote knockout mice (VDAC1+/-) and dynamin-related protein 1 heterozygote knockout mice (Drp1+/-); and maintaining different lines mice (APP, Tau, VDAC1+/- X APP, VDAC1 X Tau, Drp1+/-, Drp1+/- X APP and Drp1+/- X Tau) and assessing cognitive behavior using rotarod, morris water maze, open field and Y-maze.

He is the member of several learned accredited bodies and review editor for many journals, and his current work investigates the mechanisms of miRNA-mRNA involvement in therapeutic response for ischemic stroke and its related vascular dementia.

  • Employee of the year for Research in recognition of outstanding performance, productivity, and dedicated service by the Department of Internal Medicine, Texas Tech University Health Sciences Center.
  • Best Oral presentation award recipient entitled “Novel microRNA PC-5P-12969 as Potential Peripheral Biomarker for Ischemic Stroke”. Regional Healthy Aging and Dementia Research Symposium Organized by Garrison Institute on Aging of Texas Tech University Health Sciences.
  • Newton International Fellowship 2015 Round 2, Royal Society of London and the Science and Engineering Board of India (SERB), through the Newton- Bhabha Fund (Un-availed). 
  • He is the recipient of the FIMSA/IIS travel bursary award.
  • Presented a talk on “Protective Effects of a Small Molecule Inhibitor, DDQ Against Aging, Amyloid Beta, and Phosphorylated Tau in Alzheimer’s Disease”, Murali Vijayan, in Alzheimer’s Disease Research Seminar Series, Department of Internal Medicine, Lubbock, Texas, USA. February 23, 2021.
  • Poster presentation on “Is Alzheimer’s a Lifestyle Disease: A Critical Assessment?”. Kiran Ali, Neha Sawant, Subodh Kumar, Murali Vijayan, Bhagavathi Ramasubramanian, Pradeepkiran Jangampalli Adi, LisaAnn Gittner, Hafiz Khan and P. Hemachandra Reddy. 32nd Annual Student Research Week – 20/20 Visions of Biochemistry, March 10-13, 2020, Texas Tech University Health Sciences Center (TTUHSC), Lubbock, Texas.
  • Poster presentation on “Mitochondrial division inhibitor 1 (Mdivi1) improves ER-mitochondria contacts in Huntington’s disease”. Neha Sawant, Subodh Kumar, Murali Vijayan, Bhagavathi Ramasubramanian, Pradeepkiran Jangampalli Adi, and P. Hemachandra Reddy. 32nd Annual Student Research Week – 20/20 Visions of Biochemistry, March 10-13, 2020, Texas Tech University Health Sciences Center (TTUHSC), Lubbock, Texas.
  • Presented a poster on “Emerging roles of microRNAs in ischemic stroke and vascular dementia: possible diagnostic and therapeutic targets”. Vijayan M, Kumar S, Neha S, Reddy PH. Texas Alzheimer’s Research and Care Consortium 2020 Scientific Symposium - An Investigator Meeting, The University of Texas at Austin, Thursday, January 30, 2020.
  • Poster presentation on “MicroRNA-455-3p as a emerging peripheral biomarker for Alzheimer’s disease”. Subodh Kumar, Murali Vijayan, Neha Sawant, and P. Hemachandra Reddy. Texas Alzheimer’s Research and Care Consortium 2020 Scientific Symposium - An Investigator Meeting, The University of Texas at Austin, Thursday, January 30, 2020.
  • Presented a poster on “Novel microRNA PC-5P-12969 and ischemic stroke”. M. Vijayan, P.H. Reddy. Neuroscience 2019, 19-23rd October 2019.
  • Presented an talk on “MicroRNAs: innovative targets for ischemic stroke”, Murali Vijayan, in Alzheimer’s Disease Research Seminar Series, Department of Internal Medicine, Lubbock, Texas, USA.
  • Presented an oral on “Novel microRNA PC-5P-12969 as Potential Peripheral Biomarker for Ischemic Stroke”, Murali Vijayan, P. Hemachandra Reddy. Regional Healthy Aging and Dementia Research Symposium Organized by Garrison Institute on Aging of Texas Tech University Health Sciences Center held on 24-25th October, 2018, Lubbock, Texas, USA.
  • Presented a poster on “Expression Level of Novel Mirna Pc-5P-12969 in Two Different in vivo Stroke Models”. Vijayan M, Kumar S, Cengiz P, Karamyan VT, Reddy PH. Regional Healthy Aging and Dementia Research Symposium Organized by Garrison Institute on Aging of Texas Tech University Health Sciences Center held on 24-25th October, 2018, Lubbock, Texas, USA.
  • Poster presentation on “MicroRNA-455-3p regulates amyloid precursor protein processing, mitochondrial biogenesis and synaptic activity in Alzheimer’s disease”. Subodh Kumar, Murali Vijayan, Arubala P Reddy, Xiangling Yin and P. Hemachandra Reddy. Regional Healthy Aging and Dementia Research Symposium Organized by Garrison Institute on Aging of Texas Tech University Health Sciences Center held on 24-25th October, 2018, Lubbock, Texas, USA.
  • Poster presentation on “Reduced Dynamin-Related Protein 1 Mitigates Mitochondrial Fragmentation, Elevates Spatial Learning and Memory Functions and Elevates Dendritic Spines in App Transgenic Mice”. Maria Manczak, Ramesh Kandimalla, Xiangling Yin, Murali Vijayan, Chandra Sekhar Kuruva, Subodh Kumar, P. Hemachandra Reddy. Regional Healthy Aging and Dementia Research Symposium Organized by Garrison Institute on Aging of Texas Tech University Health Sciences Center held on 24-25th October, 2018, Lubbock, Texas, USA.
  • Poster presentation on “Age- and Gender-Based MicroRNA Levels in C57BL6/J mice”. Christopher Hornback, Subodh Kumar, Murali Vijayan, C. Breann Williams, Pratibha Kottapalli, Rao Kottapalli, P. Hemachandra Reddy. Regional Healthy Aging and Dementia Research Symposium Organized by Garrison Institute on Aging of Texas Tech University Health Sciences Center held on 24-25th October, 2018, Lubbock, Texas, USA.
  • Oral presentation on “Improvement in risk factors implicated in Alzheimer’s Disease Pathogenesis”. Hegde V, Vijayan M, Peddibhotla S, Kumar S, Dhurandhar NV, and Reddy H. American Society for Nutrition 2018. 9-12th June, 2018.
  • Presented a poster on “Identification of novel circulatory microRNA signatures linked to patients with stroke”.  M. Vijayan, S. Kumar, P.H. Reddy. Neuroscience 2017, 11-15th November, 2017.
  • Poster presentation on “MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer’s disease”. S. Kumar, M. Vijayan, P.H. Reddy. Neuroscience 2017, 11-15th November, 2017.
  • Poster presentation on “Reduced dynamin-related protein 1 mitigates mitochondrial fragmentation, elevates spatial learning and memory functions and elevates dendritic spines in app transgenic mice”. M. Manczak, R. Kandimalla, M. Vijayan, X. Yin, C. Kuruva, S. Kumar, P.H. Reddy. Neuroscience 2017, 11-15th November, 2017.
  • Poster presentation on “A partial loss of dynamin-related protein 1 enhances dendritic spines, reduces fragmented mitochondria and increases hippocampal based cognitive function in mutant Tau mice”. R. Kandimalla, M. Manczak, X. Yin, C. S. Kuruva, M. Vijayan, S. Kumar, P.H. Reddy. Neuroscience 2017, 11-15th November, 2017.
  • Poster presentation on “Polymorphic amino acid variations in the peptide binding pockets of HLA-DQB1* alleles with autoimmune thyroid disease from south India”. Ramgopal S, Rathika C, Padma Malini R, Vijayan M, Balakrishnan K. American Society for Histocompatibility & Immunogenetics (AHSI) 43rd Annual meeting, 11-15th September, 2017.
  • Poster presentation on “Presence of HLA extended haplotypes and KIR association in health and diseases in South India”. Balakrishnan K, Rathika C, Vijayan M, Padma Malini R, Ramgopal S. American Society for Histocompatibility & Immunogenetics (AHSI) 43rd Annual meeting, 11-15th September, 2017.
  • Poster presentation on “MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer’s disease”. Kumar S, Vijayan M, Reddy PH. Symposium of the Center of Excellence for Translational Neuroscience and Therapeutics, April 27, 2017.
  • Poster presentation on “Differential expression of microRNAs in the skeletal muscles of mice with aging”. Williams J, Smith F, Kumar S, Vijayan M, Reddy PH. 29th Annual Student Research Week - Molecular Neurosciences & Systems: From Nucleotides to Networks, March 7-10, 2017.
  • Poster presentation on “Up regulation of microRNAs in the brains of mice with aging”. Smith F, Williams J, Kumar S, Vijayan M, Reddy PH. 29th Annual Student Research Week - Molecular Neurosciences & Systems: From Nucleotides to Networks, March 7-10, 2017.
  • Presented a poster on “Studies on HLA-hsp70 gene expression among frequent users of mobile phone”. Vijayan M, Balakrishnan K, Rathika C. 5th Congress of the Federation of Immunological Societies of Asia Oceania: March 14-17, 2012.
  • Presented a poster on “An analysis of host genetics (HLA) and the expression of heat shock proteins (hsp) among mobile phone users”. K. Balakrishnan, Vijayan M, C. Rathika, T. Manikandan, International conference on Defence Science & Research, Singapore on 3-5th August 2011.
  1. Hegde V, Vijayan M, Kumar S, Akheruzzaman M, Sawant N, Dhurandhar NV, Reddy PH. Adenovirus 36 improves glycemic control and markers of Alzheimer's disease pathogenesis. Biochim Biophys Acta Mol Basis Dis. 2019 Aug 6;. doi: 10.1016/j.bbadis.2019.08.007. [Epub ahead of print] PubMed PMID: 31398466.
  2. Chinniah R, Rajendran MS, Sivanadham R, Adaikalam ML, Ravi PM, Vijayan M, Boopathy S, Pandi S, Sevak V, Karuppiah B. Association of HLA class II alleles/haplotypes and amino acid variations in the peptide binding pockets with rheumatoid arthritis. Int J Rheum Dis. 2019 Jun 6;. doi: 10.1111/1756-185X.13612. [Epub ahead of print] PubMed PMID: 31169355.
  3. Reddy PH, Swerdlow RH, Culberson J, Kang D, Mitchell TL, Smith Q, Suneja S, Ory MG, Kumar S, Vijayan M, Morsy A, Arandia G, Lawrence JJ, George E, Oliver D, Pradeepkiran JA, Yin X, Reddy AP, Manczak M, Cengiz P, Karamyan VT, Kandimalla R, Kuruva CS, Willms J, Ramasubramanian B, Sawant N, Burugu D, Boles AN, Lopez V, Carrasco R, Aguirre C, Thompson S, Blackmon J, Ament C, Wang R, Stephens ER, Hoang B, Bass K, Trippier PC, Hornback C, Kottapalli P, Kottapalli KR, Oddo S. Current Status of Healthy Aging and Dementia Research: A Symposium Summary. J Alzheimers Dis. 2019 May 17;. doi: 10.3233/JAD-190252. [Epub ahead of print] PubMed PMID: 31104030.
  4. Vijayan M, Alamri FF, Al Shoyaib A, Karamyan VT, Reddy PH. Novel miRNA PC-5P-12969 in Ischemic Stroke. Mol Neurobiol. 2019 Apr 5;. doi: 10.1007/s12035-019-1562-x. [Epub ahead of print] PubMed PMID: 30953313.
  5. Chinniah R, Vijayan M, Sivanadham R, Ravi P, Panneerselvam D, Kannan A, Karuppiah B. Diversity and association of HLA/KIR receptors with type 2 diabetes in South India. Int J Immunogenet. 2019 Feb 27;. doi: 10.1111/iji.12417. [Epub ahead of print] PubMed PMID: 30809938.
  6. Ramgopal S, Rathika C, Padma Malini R, Murali V, Arun K, Balakrishnan K. Critical amino acid variations in HLA-DQB1* molecules confers susceptibility to Autoimmune Thyroid Disease in south India. Genes Immun. 2019 Jan;20(1):32-38. doi: 10.1038/s41435-017-0008-6. Epub 2018 Jan 8. PubMed PMID: 29307887.
  7. Kumar Ramanathan AS, Karuppiah B, Vijayan M, Raju K, Mani D, Chinniah R, Thirunavukkarasu M, Malini Ravi P, Illiayaraja Krishnan J, Senguttuvan P. Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome. J Biomed Res. 2018 Oct 16;. doi: 10.7555/JBR.32.20150095. [Epub ahead of print] PubMed PMID: 30333281.
  8. Padma-Malini R, Rathika C, Ramgopal S, Murali V, Dharmarajan P, Pushkala S, Balakrishnan K. Associations of CTLA4 +49 A/G Dimorphism and HLA-DRB1*/DQB1* Alleles With Type 1 Diabetes from South India. Biochem Genet. 2018 Oct;56(5):489-505. doi: 10.1007/s10528-018-9856-7. Epub 2018 Mar 30. PubMed PMID: 29603038.
  9. Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP. Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease. Hum Mol Genet. 2018 Jul 15;27(14):2502-2516. doi: 10.1093/hmg/ddy154. PubMed PMID: 29701781; PubMed Central PMCID: PMC6031001.
  10. Vijayan M, Kumar S, Yin X, Zafer D, Chanana V, Cengiz P, Reddy PH. Identification of novel circulatory microRNA signatures linked to patients with ischemic stroke. Hum Mol Genet. 2018 Jul 1;27(13):2318-2329. doi: 10.1093/hmg/ddy136. PubMed PMID: 29701837; PubMed Central PMCID: PMC6005038.
  11. Ramgopal S, Rathika C, Padma MR, Murali V, Arun K, Kamaludeen MN, Balakrishnan K. Interaction of HLA-DRB1* alleles and CTLA4 (+49 AG) gene polymorphism in Autoimmune Thyroid Disease. Gene. 2018 Feb 5;642:430-438. doi: 10.1016/j.gene.2017.11.057. Epub 2017 Nov 22. PubMed PMID: 29174716.
  12. Reddy PH, Manczak M, Yin X, Grady MC, Mitchell A, Tonk S, Kuruva CS, Bhatti JS, Kandimalla R, Vijayan M, Kumar S, Wang R, Pradeepkiran JA, Ogunmokun G, Thamarai K, Quesada K, Boles A, Reddy AP. Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease. J Alzheimers Dis. 2018;61(3):843-866. doi: 10.3233/JAD-170512. Review. PubMed PMID: 29332042; PubMed Central PMCID: PMC5796761.
  13. Mani D, Chinniah R, Ravi P, Swaminathan K, Janarthanan RA, Vijayan M, Raju K, Karuppiah B. Predisposition of Angiotensin-converting Enzyme Deletion/Deletion Genotype to Coronary Artery Disease with Type 2 Diabetes Mellitus in South India. Indian J Endocrinol Metab. 2017 Nov-Dec;21(6):882-885. doi: 10.4103/ijem.IJEM_215_17. PubMed PMID: 29285453; PubMed Central PMCID: PMC5729678.
  14. Kumar S, Vijayan M, Reddy PH. MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer's disease. Hum Mol Genet. 2017 Oct 1;26(19):3808-3822. doi: 10.1093/hmg/ddx267. PubMed PMID: 28934394; PubMed Central PMCID: PMC6075184.
  15. Williams J, Smith F, Kumar S, Vijayan M, Reddy PH. Are microRNAs true sensors of ageing and cellular senescence?. Ageing Res Rev. 2017 May;35:350-363. doi: 10.1016/j.arr.2016.11.008. Epub 2016 Nov 27. Review. PubMed PMID: 27903442; PubMed Central PMCID: PMC5357446.
  16. Reddy PH, Tonk S, Kumar S, Vijayan M, Kandimalla R, Kuruva CS, Reddy AP. A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease. Biochem Biophys Res Commun. 2017 Feb 19;483(4):1156-1165. doi: 10.1016/j.bbrc.2016.08.067. Epub 2016 Aug 12. Review. PubMed PMID: 27524239; PubMed Central PMCID: PMC5343756.
  17. Kumar S, Vijayan M, Bhatti JS, Reddy PH. MicroRNAs as Peripheral Biomarkers in Aging and Age-Related Diseases. Prog Mol Biol Transl Sci. 2017;146:47-94. doi: 10.1016/bs.pmbts.2016.12.013. Epub 2017 Feb 8. Review. PubMed PMID: 28253991.
  18. Reddy PH, Williams J, Smith F, Bhatti JS, Kumar S, Vijayan M, Kandimalla R, Kuruva CS, Wang R, Manczak M, Yin X, Reddy AP. MicroRNAs, Aging, Cellular Senescence, and Alzheimer's Disease. Prog Mol Biol Transl Sci. 2017;146:127-171. doi: 10.1016/bs.pmbts.2016.12.009. Epub 2017 Feb 2. Review. PubMed PMID: 28253983.
  19. Vijayan M, Kumar S, Bhatti JS, Reddy PH. Molecular Links and Biomarkers of Stroke, Vascular Dementia, and Alzheimer's Disease. Prog Mol Biol Transl Sci. 2017;146:95-126. doi: 10.1016/bs.pmbts.2016.12.014. Epub 2017 Feb 1. Review. PubMed PMID: 28253992.
  20. Ramanathan AS, Vijayan M, Rajagopal S, Rajendiran P, Senguttuvan P. WT1 and NPHS2 gene mutation analysis and clinical management of steroid-resistant nephrotic syndrome. Mol Cell Biochem. 2017 Feb;426(1-2):177-181. doi: 10.1007/s11010-016-2889-5. Epub 2016 Nov 25. PubMed PMID: 27885584.
  21. Bhatti JS, Kumar S, Vijayan M, Bhatti GK, Reddy PH. Therapeutic Strategies for Mitochondrial Dysfunction and Oxidative Stress in Age-Related Metabolic Disorders. Prog Mol Biol Transl Sci. 2017;146:13-46. doi: 10.1016/bs.pmbts.2016.12.012. Epub 2017 Feb 1. Review. PubMed PMID: 28253984.
  22. Chinniah R, Vijayan M, Sivanadham R, Ravi PM, Panneerselvam D, Karuppiah B. Association of HLA-A, B, DRB1* and DQB1* alleles and haplotypes in south Indian T2DM patients. Gene. 2016 Oct 30;592(1):200-208. doi: 10.1016/j.gene.2016.08.001. Epub 2016 Aug 3. PubMed PMID: 27496342.
  23. Vijayan M, Chinniah R, Ravi PM, Sivanadham R, Mosses Joseph AK, Vellaiappan NA, Krishnan JI, Karuppiah B. MTHFR (C677T) CT genotype and CT-apoE3/3 genotypic combination predisposes the risk of ischemic stroke. Gene. 2016 Oct 15;591(2):465-70. doi: 10.1016/j.gene.2016.06.062. Epub 2016 Jul 1. PubMed PMID: 27378745.
  24. Vijayan M, Reddy PH. Peripheral biomarkers of stroke: Focus on circulatory microRNAs. Biochim Biophys Acta. 2016 Oct;1862(10):1984-93. doi: 10.1016/j.bbadis.2016.08.003. Epub 2016 Aug 5. Review. PubMed PMID: 27503360; PubMed Central PMCID: PMC5343760.
  25. Vijayan M, Reddy PH. Stroke, Vascular Dementia, and Alzheimer's Disease: Molecular Links. J Alzheimers Dis. 2016 Sep 6;54(2):427-43. doi: 10.3233/JAD-160527. Review. PubMed PMID: 27567871; PubMed Central PMCID: PMC5793908.
  26. Ramanathan AS, Senguttuvan P, Chinniah R, Vijayan M, Thirunavukkarasu M, Raju K, Mani D, Ravi PM, Rajendran P, Krishnan JI, Karuppiah B. Association of HLA-DR/DQ alleles and haplotypes with nephrotic syndrome. Nephrology (Carlton). 2016 Sep;21(9):745-52. doi: 10.1111/nep.12669. PubMed PMID: 26566811.
  27. Chinniah R, Vijayan M, Thirunavukkarasu M, Mani D, Raju K, Ravi PM, Sivanadham R, C K, N M, Karuppiah B. Polymorphic Alu Insertion/Deletion in Different Caste and Tribal Populations from South India. PLoS One. 2016;11(6):e0157468. doi: 10.1371/journal.pone.0157468. eCollection 2016. PubMed PMID: 27315142; PubMed Central PMCID: PMC4912101.
  28. Murali V, Rathika C, Ramgopal S, Padma Malini R, Arun Kumar MJ, Neethi Arasu V, Jeyaram Illiayaraja K, Balakrishnan K. Susceptible and protective associations of HLA DRB1*/DQB1* alleles and haplotypes with ischaemic stroke. Int J Immunogenet. 2016 Jun;43(3):159-65. doi: 10.1111/iji.12266. Epub 2016 Apr 22. PubMed PMID: 27105925.
  29. Rathika C, Murali V, Dhivakar M, Kamaraj R, Malini RP, Ramgopal S, Balakrishnan K. Susceptible and Protective Associations of HLA Alleles and Haplotypes with Cervical Cancer in South India. Asian Pac J Cancer Prev. 2016;17(5):2491-7. PubMed PMID: 27268619.
  30. Vijayan M, Chinniah R, Ravi PM, Mosses Joseph AK, Vellaiappan NA, Krishnan JI, Karuppiah B. ACE-II genotype and I allele predicts ischemic stroke among males in south India. Meta Gene. 2014 Dec;2:661-9. doi: 10.1016/j.mgene.2014.09.003. eCollection 2014 Dec. PubMed PMID: 25606450; PubMed Central PMCID: PMC4287818.
  31. Balakrishnan K, Murali V, Rathika C, Manikandan T, Malini RP, Kumar RA, Krishnan M. Hsp70 is an independent stress marker among frequent users of mobile phones. J Environ Pathol Toxicol Oncol. 2014;33(4):339-47. PubMed PMID: 25404380.