TTUHSC School of Medicine
HomeSchool of MedicineCell Physiology and Molecular BiophysicsFacultyRoger B. Sutton

Roger B. Sutton, Ph.D.


Biochemistry/Structural Biology

The University of Texas Southwestern Medical Center

Dallas, TX


Curriculum Vitae

Research Interests: X-ray crystallography, membrane fusion, C2 domain biophysics (synaptotagmin and dysferlin)

Ongoing Projects

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Publications:                                            H-index

 1 Shaffer, J.B, Sutton RB and Bewley, G.C. Isolation of a cDNA Clone for Murine Catalase and Analysis of an Acatalasemic Mutant. J. Biol Chem. Sept 25, 262(27): 12908-11, 1987.
2 Sutton, R.B, Davletov, B.A., Berghuis, A.M., Sudhof, T.C., and Sprang, S.R.Structure of the First C2 domain of Synaptotagmin I: A novel Ca+2/ dependent phospholipid-binding Fold. Cell. 80. 938; 1995.
3  Rizo, J., Sutton, R.B., Breslau, J., Koerber, S.C., Porter, J., Hagler, A.T., Gierasch, L., and Rivier, J. (1996). A Novel Conformation in a Highly Potent, Constrained Gonadotrophin Releasing Hormone Antagonist. Journal of the American Chemical Society, 118(5):970-976; 1996.
  Shao, X., Davletov, B.A., Sutton, R.B., Sudhof, T.C. and Rizo, J. Bipartite Ca+2-binding Motif in C2 domains of Synaptotagmin and Protein Kinase C. Science. 273:248-251; 1996.
  Fasshauer, D., Sutton, R.B., Brunger, A.T., and Jahn, R.. Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R- SNAREs. Proceedings of the National Academy of Sciences USA, 95:15781-15786; 1998.
  Sutton, R.B. and Sprang, S.R. Structure of the Protein Kinase Cß phospholipid-binding C2 domain complexed with Ca2+. Structure, 6(11):1395-1405; 1998.
  Sutton, R.B., Fasshauer, D., Jahn, R., and Brunger, A.T. Crystal Structure of a SNARE Complex involved in synaptic exocytosis at 2.4 Å Resolution. Nature 395:347-353; 1998.
  Sutton, R.B., Ernst, J., and Brunger, A.T. Crystal Structure of cytosolic C2A-C2B domains of synaptotagmin III. Journal of Cell Biology, 147:589-598; 1999.
  Furst, H., Sutton, R.B., Brunger, A.T., Grigorieff, N., Three-Dimensional Structure of the AAA ATPase, NSF, at 11 Å resolution. EMBO J 22 (17):4365-4374; 2003.
  Sieger, K.A., Mhashilkar, A.M., Stewart, A., Sutton, R.B., Strube, R.W., Chen, S-Y., Pataer, A., Swisher, S.G., Ramesh, R., Chada, S. The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells. Molecular Therapy 9(3), 355-367, 2004.
  Chada,S., Mhashilkar, A.M., Ramesh, R., Mumm, J.B., Sutton R.B., Bocangel, D., Zheng, M., Grimm, E.A. and Ekmekcioglu, S., Bystander activity of Ad-mda7: Human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism, Molecular Therapy 10(6), 1085-1095, 2004.
  Chada, S., Sutton, R.B., Ekmekcioglu, S., Ellerhorst, J., Mumm, J.B., Leitner, W.W., Yang, H.Y., Sahin, A.A., Hunt, K.K., Fuson, K.L., Poindexter, N., Roth, J.A., Ramesh, R., Grimm,E.A., Mhashilkar, A.M., MDA-7/IL-24 is a unique cytokine-tumor suppressor in the IL-10 family, Int Immunopharmacol. 4(5), 649-667, 2004.
  Sutton, R.B., Navarro, J.,Gurevich, V.V., X-ray crystal structure of Ambystoma cone arrestin at 2.3 Å resolution. Journal of Molecular Biology, 354(5), 1069-80, 2005. (cover art).
  Peng, B-H., Anderson, J., Lee, J.C., Sutton, R.B., Crystallization and preliminary X-ray diffraction of the ZO-binding domain of human occludin. Acta Cryst., F61, 2005.
  Montes, M, Fuson, KL., Sutton, RB, and Robert, JJ. Purification, crystallization and X-ray diffraction analysis of human synaptotagmin 1 C2A-C2B.Acta Cryst. , F62, p.926, 2006.
  Lagow, R.D., Bao, H., Cohen, E.N., Daniels, R.W., Zuzek, A., Williams, W.H., MacLeod, G.T., Sutton, R.B. and Zhang, B. Modification of a hydrophobic layer by a point mutation in Syntaxin 1A regulates the rate of synaptic vesicle fusion. PLoS Biology,5(4), e72, 2007.
  Fuson, KL, Montes, M, Robert, JJ, Sutton, RB. Structure of human synaptotagmin 1 C2AB in the absence of Ca+2 reveals a novel domain association. Biochemistry, 46, 13041-13048, 2007.(cover art).
  Greene, D., Garcia, T., Sutton, R.B., Gernert, K.M., Benian, G.M., Oberhauser, A.F., Single-molecule force spectroscopy reveals a stepwise unfolding of C. elegans giant protein kinase domains. Biophysical Journal, Apr 4, 2008 (cover art).
  Fuson, K.L., Sutton.R.B. and Oberhauser, A.F., The C2 domains of human Synaptotagmin 1 have distinct mechanical properties. Biophysical Journal, 96, 1083-1090, 2009.
  McDowell, CL, Sutton, R.B., Obermann, W.M.J., Expression of Hsp90 chaperone proteins in human tumor tissue. International Journal of Biological Macromolecules, 45(3), 310-314, 2009.
  Fuson, K.L., Zheng, M, Patear, A, Rajagopal, R., Chada, S., Sutton, R.B., Structural mapping of post-translational modifications in human interleukin-24: The role of N-linked glycosylation and disulfide bonds in proper secretion and activity, JBC, 44, 30526-33, 2009.
  Vrljic,M, Strop, P, Ernst. JA, Sutton, RB, Chu,S, Brunger, AT, Molecular mechanism of the synaptotagmin–SNARE interaction in Ca2+, Nature Structural and Molecular Biology, NSMB, 17(3), 325-31, 2010.
  Lek A, Evesson FJ, Sutton RB, North KN, Cooper ST. Ferlins; regulators of vesicle fusion for auditory neurotransmission, receptor trafficking and membrane repair. Traffic, Aug. 12, 2011.
  Niwayama S, Kassar, A.S., Zhao, T., Sutton, RB, Altenberg, GA. A Pyrene Maleimide with a Flexible Linker for Sampling of Longer Inter-Thiol Distances by Excitamer Formation. 6(10):e26691, 2011.
  Kim SG, Chung JS, Sutton RB, Lee JS, Lopez-Maury L, Lee SY, et al. Redox, mutagenic and structural studies of the glutaredoxin/arsenate reductase couple from the cyanobacterium Synechocystis sp. PCC 6803. Biochimica et Biophysica Acta. ;1824(2):392-403, 2012.
  Gauer JW, Sisk R, Murphy JR, Jacobson H, Sutton RB, Gillispie GD, Hinderliter A. Mechanism for Calcium Ion Sensing by the C2A Domain of Synaptotagmin I. Biophysical journal. 103(2):238-46. 2012.
  Zoghbi ME, Fuson KL, Sutton RB, Altenberg GA. Kinetics of the association/dissociation cycle of an ATP-binding cassette nucleotide-binding domain. J Biol Chem. Feb 3;287(6):4157-64, 2012.
  Fealey ME, Gauer JW, Kempka SC, Miller K, Nayak K, Sutton RB, Hinderliter A. Negative coupling as a mechanism for signal propagation between C2 domains of synaptotagmin I. PLoS One.;7(10):e46748, 2012.
  McCann JJ, Zheng L, Rohrbeck D, Felekyan S, Kühnemuth R, Sutton RB, Seidel CA, Bowen ME. Supertertiary structure of the synaptic MAGuK scaffold proteins is conserved. Proc Natl Acad Sci U S A. Sep 25;109(39):15775-80, 2012.
  Striegel AR, Biela LM, Evans CS, Wang Z, Delehoy JB, Sutton RB, Chapman ER, Reist NE. Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. J Neurosci. Jan 25;32(4):1253-60. 2012.
  Xu M, Ma L, Bujalowski PJ, Qian F, Sutton RB, Oberhauser AF. Analysis of the REJ Module of Polycystin-1 Using Molecular Modeling and Force-Spectroscopy Techniques. J Biophys. Epub 2013 May 26. 2013
  Fuson K., Rice A., Mahling R., Snow A., Nayak, K., Shanbhogue P., Meyer AG., Redpath G., Hinderliter AH., Cooper ST., Sutton RB. Alternate splicing of dysferlin C2A confers Ca2+-dependent and Ca2+-independent binding for membrane repair. Structure. Jan 7;22(1): 104-115, 2014.
  Knaff, DB and Sutton, RB. Utility of Synechocystis sp. PCC 6803 glutaredoxin A as a platform to study high-resolution mutagenesis of proteins. Frontiers in Plant Sci. Nov 15;4:461, 2013.
Tripathy JN, Hirasawa M, Sutton RB, Dasgupta A, Vaidyanathan N, Zabet-Moghaddam M, Florencio FJ, Srivastava AP, Knaff DB. A loop unique to ferredoxin-dependent glutamate synthases is not absolutely essential for ferredoxin-dependent catalytic activity.Photosynthesis Research, Feb; 123(2), 129-139, 2015.
Ferrari R, Ferrara M, Alinani A, Sutton RB, Fama F, Picco A, Rodriguez G, Nobili F, Momeni P. Screening of Early and Late Onset Alzheimer's Disease Genetic Risk Factors in a Cohort of Dementia Patients from Liguria, Italy. Curr Alzheimer Res. Jul 10., 2015.