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Profile for Constantinos Mikelis

Constantinos Mikelis

Constantinos Mikelis

  • Assistant Professor SOP Biomedical Sciences Amarillo
Office Phone: 806-414-9242
Mail Address: 1406 S Coulter St, Amarillo Research Building
Amarillo TX 79106


B.S. Biology (2002), University of Patras, Greece.
M.S. Molecular Pharmacology (2004), University of Patras, Greece.
Ph.D. Molecular Pharmacology (2009), University of Patras, Greece.
Sabbatical Training (2009), German Cancer Research Center (dkfz), Heidelberg, Germany.
Postdoc (2009-2014), Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, MD.

Research Interests

The focus of my lab is in the area of vascular biology. We are interested in the role of endothelial cells (cells lining the inner surface of blood and lymphatic vessels) in physiological functions and in various diseases, including cancer. A special focus of the lab is to study the role of a protein, the small GTPase RhoA, on endothelial physiology in pathological conditions with a therapeutic perspective.

Selected Publications:

  • Doçi CL, Mikelis C, Lionakis MS, Molinolo AA, Gutkind JS. Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma.. Cancer research 2015.
  • Mikelis C, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.. Nature communications 2015;6:6725.
  • Dillenburg-Pilla P, Patel V, Mikelis C, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, Gutkind JS. SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015;29(3):1056-68.
  • Gan CP, Patel V, Mikelis C, Zain RB, Molinolo AA, Abraham MT, Teo SH, Abdul Rahman ZA, Gutkind JS, Cheong SC. Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.. Oncotarget 2014;5(20):9626-40.
  • Lionakis MS, Swamydas M, Fischer BG, Plantinga TS, Johnson MD, Jaeger M, Green NM, Masedunskas A, Weigert R, Mikelis C, Wan W, Lee CC, Lim JK, Rivollier A, Yang JC, Laird GM, Wheeler RT, Alexander BD, Perfect JR, Gao JL, Kullberg BJ, Netea MG, Murphy PM. CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.. The Journal of clinical investigation 2013;123(12):5035-51.