Profile for Tom Abbruscato, PhD

Tom Abbruscato

Tom Abbruscato, PhD

  • Chair of Pharmaceutical Sciences
  • Professor and Chair of Pharmaceutical Sciences
  • Associate Dean
Office Phone: 806-414-9234
Mail Address: 1300 South Coulter
Amarillo TX 79106


The research of Dr. Abbruscato's Lab includes approaches to understand the mechanisms by which the neurovascular unit responds to brain ischemia with respect to transport protein expression, cell-cell interactions, and the transport of drugs, ions and nutrients that are vital for brain recovery after stroke. We utilize a variety of in vitro blood-brain barrier models to both measure drug and nutrient uptake/transport and to characterize the mechanisms involved in the maintenance of the paracellular barrier during pathophysiologic states. The overall goal of our lab is to make significant preclinical discoveries that will translate clinically to novel treatment options for stroke patients, which unfortunately to this date do not have many viable therapeutic options to improve brain recovery after stroke.

Research Interests

brain drug transport
blood-brain barrier
opioid receptors

Clinical Interests

stroke, smoking and diabetes

Selected Publications:

  • Yang L, Islam MR, Karamyan VT, Abbruscato TJ. In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment.. Brain research 2015;1609:1-11.
  • Davis TP, Abbruscato TJ, Egleton RD. Peptides at the blood brain barrier: Knowing me knowing you.. Peptides 2015.
  • Shah KK, Boreddy PR, Abbruscato TJ. Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood-brain barrier in mice.. Fluids and barriers of the CNS 2015;12:10.
  • Egleton RD, Abbruscato TJ. Drug abuse and the neurovascular unit. Adv Pharmacol. 2014;(71):451-80.
  • Rashid M, Wangler NJ, Yang L, Shah K, Arumugam TV, Abbruscato TJ, Karamyan VT. Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain.. Journal of Neurochemistry 2014;129(1):179-89.