Profile for Thomas Thekkumkara

Thomas Thekkumkara

Thomas Thekkumkara

  • Professor
  • Department Chairperson
  • Regional Dean
  • Visiting Professor
Office Phone: 806-414-9267
Mail Address: 1300 South Coulter
Amarillo TX 79106

Research Interests

I am primarily interested in molecular mechanisms of activation and regulation of G-protein coupled receptors. I have focused on the receptor for the potent hormone; angiotensin II as a model for the subfamily of G-protein coupled receptors, which bind peptide ligands. Angiotensin II is the effector of the renin-angiotensin system, which plays a critical role in blood pressure regulation and electrolyte balance and which has been implicated in many important medical disorders, including hypertension and diabetes with its associated cardiovascular and renal damage. Consequently, investigating the biochemical and molecular mechanisms of Angiotensin II receptor activation and regulation is crucial for understanding the physiology and pathophysiology of the renin-angiotensin system.

Teaching Interests

Teaching college students especially in a professional school is both challenging and rewarding. I feel that students need to develop skills for efficient assimilation and interpretation of information. Therefore, they need to know how to think for themselves. I consider it my responsibility to help students learn how to think critically. My expertise is well suited for teaching courses on molecular and cellular biology underlying physiological and pathophysiological processes. Since coming to Texas Tech, my teaching responsibilities here at the School of Pharmacy involve both professional and graduate students. I am an instructional member on several didactic courses including, Pharmacotherapy-Cardiovascular, Principles of Diseases, Case Studies I Tutorial and Pharmaceutical Sciences Cancer Biology, Advanced Principles of Disease, and Research Design and Analysis.

Selected Publications:

  • Pillai VC, Snyder RO, Gumaste U, Thekkumkara TJ, Mehvar R. Effects of Transient Overexpression or Knockdown of Cytochrome P450 Reductase on Reactive Oxygen Species Generation and Hypoxia-Reoxygenation Injury in Liver Cells.. Clin. Exp. Pharmacol. Physiol. 2011;38:846-853.
  • Pillai VC, Snyder R, Gumaste U, Thekkumkara TJ, Mehvar R. Effects of transient overexpression or knockdown of cytochrome P450 reductase on reactive oxygen species generation and hypoxia reoxygenation injury in liver cells.. Clinical and experimental pharmacology & physiology 2011;38(12):846-53.
  • Koganti S, Thekkumkara TJ. 2-Methoxy Estradiol Mediated Downregulation of Angiotensin Type 1 Receptor Expression.. FASEB J. 2010;24:786.13.
  • Snyder R, Thekkumkara TJ. A Novel Mechanism for 13-cis Retinoic Acid mediated Angiotensin Type 1 Receptor Downregulation.. FASEB J. 2010;24:702.1.
  • Pillai VC, Yesudas R, Shaik IH, Thekkumkara TJ, Bickel U, Srivenugopal KS, Mehvar R. Delivery of NADPH-cytochrome P450 reductase antisense oligos using avidin-biotin approach. Bioconjug Chem 2010;21:203-207.