Pradeep Jangampalli, PhD | Texas Tech University Health Sciences Center
Pradeep Jangampalli

Pradeep Jangampalli, PhD

Postdoctoral Research Associate

 

I  received my Ph.D. in Bioinformatics from Sri Venkateswara University. In my Ph.D. findings, I undertook a challenging research problem on "Identification and characterization of potential drug targets in Brucella genomes." I identified few putative drug targets genes that are potential candidate for Brucella pathogenesis through computational studies like molecular modeling, molecular docking, molecular dynamic simulation studies, and pharmacophore in drug discovery.

Currently, I am working on a project for identification of potential drugs (small molecules) for Alzheimer's disease (AD) and other neuronal disorders. Small molecule therapeutics, neuronal interaction, molecular behavior, in vitro cells cultures and animal models tests are used for drug discovery and computational screening to find the best possible rational therapeutic small molecules for AD and other neurological disorders. I am looking at small molecules involvement of therapeutic protection with inhibition against neurodegeneration including the role of secretase and tau components, synaptic, biogenesis and mitochondrial dynamic proteins and genes role in the pathogenesis of AD including Tau and APP metabolism.

  • 2018 - Best poster award received at Regional Healthy Aging and Dementia Research Symposium at Lubbock, Texas, USA.
  • 2017 - Poster presented at Society for neuroscience (SfN) at Washington DC.
  • 2017 - Poster presented at, Center of Excellence for Translational Neuroscience and Therapeutics (CTNT), Texas Tech Health Science Center, Lubbock, Texas, USA.
  • 2015 - University Grant Commission (UGC) BSR Scholarship: The Research Meritorious Fellowship in Sciences for the outstanding PhD candidates.

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Publications

  • Jangampalli Adi Pradeepkiran, Hemachandra reddy. Structure based design and molecular docking studies for phosphorylated tau inhibitors in Alzheimer’s disease. Cells (2019), 8(3), 260; https://doi.org/10.3390/cells8030260
  • Jangampalli Adi Pradeepkiran, Arubala P Reddy, P Hemachandra Reddy. Pharmacophore-based models for therapeutic drugs against phosphorylated tau in Alzheimer’s disease. Drug Discovery Today, (2018). https://doi.org/10.1016/j.drudis.2018.11.005.
  • P. Hemachandra Reddy, XiangLin Yin, Maria Manczak, Subodh Kumar, Pradeepkiran Jangampalli Adi, Murali Vijayan, Arubala P Reddy. Mutant APP and Amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease. Human Molecular Genetics, (2018) https://doi.org/10.1093/hmg/ddy154.
  • P. Hemachandra Reddy, Maria Manczak, Xiangling Yin, Mary Catherine Grady, Andrew Mitchell, Sahil Tonk, Chandra Sekhar Kuruva, Jasvinder Singh Bhatti, Ramesh Kandimalla, Murali Vijayan, Subodh Kumar, Rui Wang, Jangampalli Adi Pradeepkiran, Gilbert Ogunmokun, Kavya Thamarai, Kandi Quesada, Annette Boles, Arubala P. Reddy. Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease. (2018) 61(3):843-866. Journal of Alzheimer's disease.
    DOI: 10.3233/JAD-170512
  • P. Hemachandra Reddy, Russell H. Swerdlow, John Culberson, David Kang, Tedd L. Mitchell,Quentin Smith, Sanoj Suneja, Marcia G. Ory, Subodh Kumar, Murali Vijayan, Ahmed Morsy, Gabriela Arandia, J. Josh Lawrence, Elizabeth George, Darryll Oliver, Jangampalli Adi Pradeepkiran, Xiangling Yin, Arubala P. Reddy, Maria Manczak, Pelin Cengiz1, Vardan T. Karamyan, Ramesh Kandimalla, Chandra Sekhar Kuruva, Joshua Willms1, Bhagavathi Ramasubramanian, Neha Sawant, Divya Burugu, Annette N. Boles, Veronica Lopez, Rocio Carrasco, Cordelia Aguirre, Susan Thompson, Joan Blackmon, Clay Ament, Rui Wang, Emily R. Stephens, Brittney Hoang, Kevin Bass, Paul C. Trippier, Christopher Hornback, Pratibha Kottapalli, Kameswara Rao Kottapalli, Center Biotechnology and Genetics Core Facility,Salvatore Oddo. Current Status of Healthy Aging and Dementia Research: A Symposium Summary. Journal of Alzheimer’s disease xx (2019) 1–25. DOI 10.3233/JAD-190252.
  • Praveen Chakravarthi Veeraragavulu, Nanda Kumar Yellapu, Sireesha Yerrathota, Pradeepkiran Jangampalli Adi, and Bhaskar Matcha, Three Novel Mutations I65S, R66S, and G86R Divulge Significant Conformational Variations in the PTB Domain of the IRS1 Gene. ACS Omega, (2019); 4, (1): 2217-2224. https://doi.org/10.1021/acsomega.8b01712
  • Jangampalli Adi Pradeepkiran, Konidala Kranthi Kumar, Y. Nanda Kumar, Matcha Bhaskar. Modeling, molecular dynamics, and docking assessment of transcription factor rho: a potential drug target in Brucella melitensis 16M. Drug Design, Development and Therapy, 2015(9) 1-16.  doi:10.2147/DDDT.S77020.
  • Jangampalli Adi Pradeepkiran, Sri Bhashyam Sainath, Konidala Kranthi Kumar, Kodali Vidya Prabhakar, Lokanada Balasubramanyam, Matcha Bhaskar. CGMD: An integrated database of cancer genes and markers. Scientific Reports (2015) 5, 12035. http://dx.doi.org/10.1038/srep12035.
  • Madhu Sudhana Saddala, Pradeepkiran Jangampalli Adi. Discovery of small molecules through pharmacophore modeling, docking and molecular dynamics simulation against Plasmodium vivax Vivapain-3 (VP-3). Heliyon, (2018) 4 (5) https://doi.org/10.1016/j.heliyon.2018.e00612
  • Somesula Swapna Rekha, Jangampalli Adi Pradeepkiran, Matcha Bhaskar. Bioflavonoid hesperidin possesses the anti-hyperglycemic and hypolipidemic property in STZ induced diabetic myocardial ischemia (DMI) in male Wister rats. Journal of Nutrition & Intermediary Metabolism, (2019). https://doi.org/10.1016/j.jnim.2018.12.004
  • Jangampalli Adi Pradeepkiran, Sainatth.S.B, kranthi kumar konidala, Matcha Bhaskar. Complete genome-wide screening and subtractive genomic approach revealed new virulence factors, potential drug targets against bio-war pathogen Brucella melitensis 16M. Drug Design, Development and Therapy (2015); 2015(9):1-16. doi:10.2147/DDDT.S76948
  • Nanda Kumar Yellapu, Kalpana Kandlapalli, Pradeepkiran Jangampalli Adi. Conformational transition pathway of R308K mutant glucokinase in presence of the glucokinase activator YNKGKA4. FEBS Open Bio (2017) https://doi.org/10.1002/2211-5463.12255
  • Pradeepkiran Jangampalli Adi, Jagadish R. Naidu, Bhaskar Matcha. Multiplex quantification of Escherichia coli, Salmonella typhi and Vibrio cholera with three DNA targets in single reaction assay. Microbial Pathogenesis. (2017) https://doi.org/10.1016/j.micpath.2017.06.010.
  • Madhu Sudaba Saddala, Ramesh Kandimalla, Pradeepkiran Jangampalli Adi, Sainath Sri Bhashyam, Usha Rani. Novel 1, 4-dihydropyridines for L-type calcium channel as antagonists for cadmium toxicity. Scientific Reports. (2017) https://doi.org/10.1038/srep45211
  • Jangampalli Adi Pradeepkiran. Aquaculture role in global food security with nutritional value: a review. Translational Animal Science, (2019); 3, 2. https://doi.org/10.1093/tas/txz012
  • Pradeepkiran Jangampalli Adi and Bhaskar Matcha. Analysis of aflatoxin B1 in contaminated feed, media, and serum samples of Cyprinus carpio L. by high-performance liquid chromatography. Food Quality and Safety, (2018); 2, (4): 199–204. https://doi.org/10.1093/fqsafe/fyy013.
  • Jangampalli Adi Pradeepkiran, Burra Siva Prasad, Vatapatri Amardev Rajesh, Matcha Bhaskar. Calcium, zinc and vitamin E ameliorate cadmium-induced renal oxidative damage in albino Wistar rats. Toxicology Reports 3 (2016) 591–597. http://dx.doi.org/10.1016/j.toxrep.2016.07.005.
  • Jangampalli Adi Pradeepkiran, Nanda Kumar Yellapu, Bhaskar Matcha, Modeling, molecular docking, elucidated catalytic binding mode of acetyl-CoA malate synthase G in Brucella melitensis 16M. Biochemistry and Biophysics Reports 8 (2016) 192–199. http://dx.doi.org/10.1016/j.bbrep.2016.08.020.
  • Madhu Sudhana Saddala, Pradeep Kiran Jangampalli Adi, Vengala Rao Patchava and Usha Rani A. Selenoergothionein as a Potential Inhibitor against Amyloid β-Protein (Aβ): Docking and Molecular Dynamics Studies. International Journal of Biomedical Data Mining, 5: 120. (2016). doi:10.4172/2090-4924.1000120.
  • Pradeep Kiran Jangampalli Adi, P. Ramesh Babu, V. Praveen Chakravathi, Matcha Bhaskar, Multiplex PCR assay for the simultaneous detection of C. perfringens, P. aeruginosa and K. pneumoniae, Pathogenesis 2, (2015); 21-26
    doi: 10.1016/j.pathog.2015.09.001.
  • Multiplex PCR assay for the simultaneous detection of C. perfringens, P. aeruginosa and K. pneumoniae, Pathogenesis (2015); 2, 21-26. http://dx.doi.org/10.1016/j.pathog.2015.09.001.
  • Pradeep Kiran Jangampalli Adi and Bhaskar Matcha. Environmental Acidification Impact on Fisheries by Changing Oxidative Markers of Liver and Intestine of Freshwater Fish Cyprinus Carpio.L. Poult Fish Wildl Sci (2016); 4:1. DOI:10.4172/2375-446X.1000146
  • Jangampalli Adi Pradeepkiran, Veeraraghavulu Praveen Chakravarthi, Yellapu Nanda Kumar, Somesula Swapna Rekha, Srinivasan Shanthi Kruti, Matcha Bhaskar. Comparison and correlation of Simple Sequence Repeats distribution in genomes of Brucella species. Bioinformation. (2011); 6(5):179-82. DOI: 10.6026/97320630006179.
  • J.A. Pradeepkiran, A. Sudheer kumar, S. Mannur Ismail, E. Madhuri, M. Bhaskar: Amelioration effect of probiotics (Cheese) and prebiotic (Garlic) on aflatoxin B1 induced hematological alterations in fresh water fish Cyprinus carpio L. Online Journal of Animal and Feed Research. (2015); 5, (4): 117-124.
  • Ravi Naik Mude, Swapna Rekha Somesula, Pradeepkiran Jangampalli Adi, Bhaskar Matcha. Diabetic regulation through blood constituents' modulations on treatment with Aloe vera in alloxan induced diabetic rats. Digest Journal of Nanomaterials and Biostructures. (2012); 7(2) 649 - 655.
  • Radha Madhavi Yeggnisetty Ramachandraiahgari, Swapna Rekha Somesula, Jangampalli Adi Pradeepkiran, Ismail Shaik Mannur, Madhuri Enamala, Bhaskar Matcha: Protective role of ethanolic extract of Aloe vera antioxidant properties on liver and kidney of streptozotocin-induced diabetic rats. Digest Journal of Nanomaterials and Biostructures (2010); 7, (1): 175-184.
  • V. Praveen Chakravarthi, Y. Nanda Kumar, K. Mahamanjunath, A. Rukmini, D. Bhavani, J. A. Pradeepkiran, T.Chiranjeevi, M. Ismail, J. Durga Prasad, M. Bhaskar: Analysis of polymorphism in Kir 6.2 gene in Type 2 diabetic patients. Asian Journal of Biomedical and Pharmaceutical Sciences. (2014); 4 (37), 15-20.
  • K. Subba Rao, J. A. Pradeepkiran, Praveen Chakravarthi Veeraraghavulu, M. Bhaskar: Effect of cadmium on antioxidant metabolic modulations in heart and muscle of female rabbits. International Journal of Pharmacy and Biological Sciences (2013); 3(1):409-415.
  • V. Praveen Chakravarthi, J. A. Pradeepkiran, M. Bhaskar: Cadmium toxicity - A health hazard and a serious environmental problem - An overview. International Journal of Pharmacy and Biological Sciences (2012); 2(4):235-246.
  • Y. Nanda Kumar, J.A. Pradeepkiran, P. Santhosh Kumar, S.Yeswanth, K. Kalpana, V. Koteswara Rao, P.V.G.K. Sarma, M. Bhaskar: Molecular Docking Assessment of Pyridone Derivatives as Glucokinase Activators. J Clin Sci Res. (2012); 1:163-73. doi.org/10.15380/2277-5706.JCSR.12.035
  • Yellapu Nanda Kumar, Pasupuleti Santhosh Kumar, Gopal Sowjenya, Valasani Koteswara Rao, Sthanikam Yeswanth, Uppu Venkateswara Prasad, Jangampalli Adi Pradeepkiran, Pvgk Sarma, Matcha Bhaskar: Comparison and correlation of binding mode of ATP in the kinase domains of Hexokinase family. Bioinformation (2012); 8 (12):543-7. DOI: 10.6026/97320630008543.