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Blaimschein, N., Hariharan, P., Manioglu, S., Guan, L., & Muller, D. J. (2023). Substrate-binding guides individual melibiose permeases MelB to structurally soften
and to destabilize cytoplasmic middle-loop C3. Structure, 31(1), 58-67 e54. https://doi.org/10.1016/j.str.2022.11.011
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Panda, A., Giska, F., Duncan., A., Welch, A., Brown, C., McAllister, R., Parameswaran,
H.Goder, J. N. D., Coleman, J., Ramakrishnan, S., Pincet, F., Guan, L., Krishnakumar,
S., Rothman, J. E., Gupta, K. (2022) Direct determination of oligomeric organization
of integral membrane proteins and lipids from intact customizable bilayer. Nature Methods (Accepted). |
Selected Publications in the Past Years |
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Guan, L. (2022) Editorial, Structure and mechanism of membrane transporters. Scientific Reports 12:13248 https://doi.org/10.1038/s41598-022-17524-1 |
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Katsube, S., Liang, R., Amin, A., Hariharan, P., & Guan, L. (2022). Molecular Basis for the Cation Selectivity of Salmonella typhimurium Melibiose
Permease. Journal of Molecular Biology, 434(12), 167598. https://doi.org/10.1016/j.jmb.2022.167598 |
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Guan, L., Hariharan, P. (2021) X-ray crystallography reveals molecular recognition
mechanism for sugar binding in a melibiose transporter MelB. Commun Biol 4, 931. https://doi.org/10.1038/s42003-021-02462-x |
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Guan, L. (2020) Glucose/Sugar Transport in Bacteria. Encyclopedia of Biochemistry, 3rd edition, Elsevier Inc. Published in the Life Sciences Reference Collection https://www.sciencedirect.com/science/article/pii/B9780128194607000931 |
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H. Ronald Kaback and Lan Guan. (2019) It takes two to tango: the dance of the permease. J Gen Physiol. 151(7):878-886. doi: 10.1085/jgp.201912377. |
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Hariharan, P., Tikhonova, E., Medeiros-Silva, J., Jeucken, A., Bogdanov, M.V., Dowhan,
W., Brouwers, J. F., Weingarth, M. and Guan, L. (2018) Structural and functional characterization of protein–lipid interactions of the Salmonella
typhimurium melibiose transporter MelB. BMC Biology 16:85 doi: 10.1186/s12915-018-0553-0 |
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Guan, L. (2018) Na(+)/Melibiose Membrane Transport Protein, MelB. In: Roberts G., Watts A., European
Biophysical Societies (eds) Encyclopedia of Biophysics. Springer. DOI: 10.1007/978-3-642-35943-9_10082-1 |
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Hariharan, P. & Guan. L. (2017) Thermodynamic cooperativity of cosubstrate binding and cation selectivity of Salmonella
typhimurium MelB. J Gen Physiol. (On the Cover and Highlighted by Research News, “A symporter’s secrets shown”). DOI:
10.1085/jgp.201711922. 149(11):1029-1039. DOI: 10.1085/jgp.201711788. |
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Ethayathulla, A.S., Yousef, M.S., Amin, A., Leblanc, G., Kaback, H.R., and Guan, L.
(2014) Structure-based mechanism for Na(+)/melibiose symport by MelB. Nature Communications. 5: 3009. DOI:10.1038/ncomms4009. |
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Chae, P.S., Rasmussen S.G.F., Rana, R., Gotfryd, K., Chandra, R., Goren, M.A., Kruse,
A.C., Nurva, S., Loland, J.C., Pierre, Y., Drew, D., Popot, J.L., Picot, D., Fox,
B.G., Guan, L., Gether, U., Byrne, B., Kobilka, B., and Gellman, S.H. (2010) Maltose–neopentyl glycol (MNG) amphiphiles for solubilization, stabilization, and
crystallization of membrane proteins. Nature Methods. 7(12):1003-1008. DOI: 10.1038/nmeth.1526. |
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Guan, L., Mirza, O., Verner, G., Iwata, S, and Kaback, H.R. (2007) Structural determination of the wild-type lactose permease. Proc Natl Acad Sci U S A, 104 (39):15294-15298. DOI: 10.1073/pnas.0707688104. |
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Guan, L. & Kaback, H.R. (2007) Site-directed alkylation of cysteine to test solvent accessibility of membrane proteins.
Nature Protocols. 2(28), 2012-2017. DOI: 10.1038/nprot.2007.275. |
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Guan, L. & Kaback, H.R. (2006) Lessons from lactose permease. Annual Review of Biophysics & Biomolecular Structure. (35):67-91.DOI: 10.1146/annurev.biophys.35.040405.102005. |