Dr. Volker Neugebauer - Faculty Page | Texas Tech University Health Sciences Center


Photo of Dr. Volker Neugebauer

Neuroplasticity in brain functions and diseases. 

The focus of my research over the past 25 years has been on synaptic and cellular neuroplastic changes in the brain in different clinically relevant conditions. A neuroscientist with background in neurology I am particularly interested in the neurobiological mechanisms of emotional-affective and cognitive aspects of disorders such as chronic pain, comorbid neuropsychiatric disorders, and neurodegenerative diseases. The analysis of emotional-affective and cognitive brain mechanisms of pain centered on the amygdala and cortico-limbic interactions is a key contribution of our work to the field of pain research and neuroscience. Our current focus on neuroimmune signaling in the brain is pioneering the analysis of neuroplasticity in pain and comorbid disorders. Collaborative basic science research projects explore brain mechanisms of neuropsychiatric disorders, alcohol use and addiction disorders, comorbidities with depression and anxiety disorders, neurodegenerative disorders such as Alzheimer's disease, and epileptogenesis. Collaborative studies in humans, including epidemiological studies, explore interventions in chronic pain and aging-related health issues including dementias and Alzheimer's disease in particular. I have been able to initiate and facilitate these collaborations across TTUHSC and TTU in my roles as Department Chair, Founding Director of the Center of Excellence for Translational Neuroscience and Therapeutics, and Executive Director and Chief Scientific Officer of the Garrison Institute on Aging (GIA), which includes oversight of Project FRONTIER, a longitudinal epidemiological study on aging and cognitive decline in a multi-ethnic sample of adults in rural communities. Our basic research program uses a multidisciplinary approach to integrate state-of-the-art in vivo and in vitro electrophysiology, multi-photon imaging in vivo and ex vivo, microendoscopy for in vivo calcium imaging, optogenetics, chemogenetics, viral vector strategies, transgenics, molecular biology, immunohistochemistry, (opto-)pharmacology, and innovative behavioral assays. My nationally and internationally recognized (h-index 54) research program has been continuously funded by NIH and has allowed me to mentor junior faculty, trainees and students. The overall goal of our translational research is the better understanding of mechanisms of neurological and psychiatric disorders to identify novel targets for new and improved diagnostic and therapeutic strategies. Generation and dissemination of knowledge about brain functions in health, aging and disease is an important goal and benefit to medical school education and graduate and postgraduate training.

  • NIH/NINDS, R01 NS120395 - " A prolactin-mediated neuroendocrine link between stress-induced latent sensitization and female-selective pain" 
    MPI, Volker Neugebauer
  • COHS AD Seed Grant - TTU - "Global gene expression profiling of high fat and fish oil effects in a mouse model of Alzheimer's disease"  
    MPI, Volker Neugebauer
  • USDA/NIFA, 2021-67017-34026 - "Ginger root extract for neuropathic pain" 
    MPI, Volker Neugebauer
  • NIH/NINDS, R01 NS118731 - "Trans-Synaptic Signaling Complex in Amygdala Pain Mechanisms" 
    MPI, Volker Neugebauer
  • NIH/NINDS, R01 NS109255 - "Pronociceptive and antinociceptive opioid mechanisms in the central nucleus of the Amygdala",
    Co-I, Volker Neugebauer
  • NIH/NINDS, R01 NS106902 - “Stress-induced descending facilitation from amygdala kappa opioid receptors in functional pain”
    MPI, Volker Neugebauer 
  • NIH/NINDS, R01 NS038261 - “Amygdala Pain Mechanisms”
    PI, Volker Neugebauer 
  • NIH/NIAAA, R01 AA027096 - “The neuroimmune model of excessive alcohol consumption: Transition to Alcohol Use Disorder”
    Co-I, Volker Neugebauer
  • Center of Excellence for Translational Neurosciences and Therapeutics, TTUHSC, PN-CTNT 2018-12 LSVNBAW - “Tai Chi for Pain Management: A Pilot Mechanistic Study”
    MPI, Volker Neugebauer


Photo of Dr. Neugebauer's lab group

Dr. Volker Neugebauer's Lab

To view information regarding Dr. Neugebauer's lab click here.


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Dr. Volker Neugebauer

(806) 743-3880