Michaela Jansen, PharmD, Ph.D. | Texas Tech University Health Sciences Center

Associate Professor of Cell Physiology and Molecular Biophysics, and of Medical Education

GSBS Concentrations: Affiliate Faculty - Biotechnology, Associate Faculty - Translational Neuroscience and Pharmacology

Foto of Michaela Jansen
 
Department of Cell Physiology and Molecular Biophysics
Center for Membrane Protein Research
Texas Tech University Health Sciences Center
3601 4th Street, STOP 6551
Lubbock, Texas 79430
Phone: (806) 743-4059
FAX: (806) 743-1512
Email: michaela.jansen@ttuhsc.edu

Research Interests

Research in the Jansen laboratory focuses on structure and function studies and pharmacology of membrane transport proteins.  Our primary focus are neurotransmitter receptors of the pentameric ligand-gated ion channel superfamily (nAChR, 5HT3, GABA). We also investigate the proton-coupled folate transporter (PCFT) that mediates (anti)folate uptake into tumors and cancer cells. PCFT therefore presents a promising therapeutic target for cancer chemotherapy.

Recent News and Views feature in Nature by Dr. Jansen.

2021 submissions to BioRxiv (open access preprint repository for the biological sciences hosted by the Cold Spring Harbor Laboratory): 

  • Currently all posts to BioRxiv have found their peer-reviewed home.

We apply techniques out of the areas of molecular biology (genetic engineering), biochemistry, chemical biology, biophysics (electrophysiology, spectroscopy, X-ray crystallography), and pharmacology to study these proteins at a molecular level.  

Funding

Current and past funding fromt he following sources is gratefully acknowledged:

National Institute of Neurological Disorders and Stroke

The CH Foundation

South Plains Foundation

CMPR, CTNT, and Office of Research at TTUHSC

Current Labmembers

For a list of past labmembers go to Jansen Labmembers

JansenLab 2019

Diversity Statement


The core foundational value of including the diverse, cultures, lifestyles, personal beliefs and ideas of all those we serve ─ and serve alongside ─ provides a positive impact on the health of our regional, national and global societies. As we pursue excellence in health care education, research and patient care, we will be ever mindful of the strength that is gained through unity in diversity.

TTUHSC Office of Diversity

Recent Publications

ncbi Antonia G. Stuebler, Michaela Jansen (2020). Mobility of Lower MA-Helices for Ion Conduction through Lateral Portals in 5-HT 3A Receptors. Biophys J. 119 (12), 2593-2603. PMID: 33157122  PMCID: PMC7822733
ncbi Antonia G. Stuebler, Michaela Jansen (2020). Bupropion Inhibits Serotonin Type 3AB Heteromeric Channels at Clinically Relevant Concentrations. Mol Pharm. 97 (3) 171-179. PMID: 31871303
ncbi Elham Pirayesh, Akash Pandhare, Antonia G. Stuebler, Michaela Jansen (2020). Delineating the Site of Interaction of the 5-HT3A Receptor with the Chaperone Protein RIC-3. Biophys J. Epub ahead of print. PMID: 31870537
ncbi Akash Pandhare, Elham Pirayesh, Antonia G. Stuebler, Michaela Jansen (2019). Triple arginines as molecular determinants for pentameric assembly of the intracellular domain of 5-HT3A receptors. J Gen Physiol. 151 (9), 1135-1145.
ncbi Michaela Jansen (2019). An in-depth structural view of a GABAA brain receptor. Nature. Epub 2019 Jan 02.
 ncbi Akash Pandhare, Antonia G Stuebler, Elham Pirayesh, Michaela Jansen (2019). A modified clear-native polyacrylamide gel electrophoresis technique to investigate the oligomeric state of MBP-5-HT3A-intracellular domain chimeras. Protein Expression and Purification. 153, 45-52.
ncbi Swapneeta S. Date, Mariana C. Fiori, Guillermo A. Altenberg, Michaela Jansen  (2017). Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1) PLOS One. 12(5):e0177572
ncbi Akash Pandhare, Aneesh Satya Pappu, Henrik Wilms, Michael Paul Blanton, Michaela Jansen (2017).  The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors. Neuropharmacology. 113(Pt A):89-99.
ncbi Akash Pandhare, Petar N. Grozdanov & Michaela Jansen (2016). Pentameric quaternary structure of the intracellular domain of serotonin type 3A receptors. Sci Rep. 6. 6:23921.
ncbi Sita Nirupama Nishtala, Nelli Mnatsakanyan, Akash Pandhare, Chun Leung, Michaela Jansen (2016). Direct interaction of the resistance to inhibitors of cholinesterase type 3 protein with the serotonin receptor type 3A intracellular domain. J Neurochem. 137(4):528-38.
ncbi Swapneeta S. Date, Cheng‐Yen Charles Chen, Yidong Chen, Michaela Jansen (2016). Experimentally optimized threading structures of the proton‐coupled folate transporter. FEBS Open Bio. 6(3):216-30.
ncbi Nelli Mnatsakanyan, S Nirupama Nishtala, Akash Pandhare, Mariana C Fiori, Raman Goyal, Jonathan E Pauwels, Andrew F Navetta,  Afzahl Ahrorov, Jansen M (2015). Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors. Biochemistry. 54(16):2670-2682. 
ncbi Phaneendra Kumar Duddempudi, Raman Goyal, Swapneeta Sanjay Date, Michaela Jansen (2013). Delineating the Extracellular Water-Accessible Surface of the Proton-Coupled Folate Transporter. PLOS One. 8(10):e78301
ncbi Phaneendra K. Duddempudi, Prachi Nakashe, Michael P. Blanton, Michaela Jansen (2013). The monomeric state of the proton‐coupled folate transporter represents the functional unit in the plasma membrane. The FEBS Journal. 280(12):2900-15.
ncbi Nelli Mnatsakanyan, Michaela Jansen (2013). Experimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptors. Journal Neurochem. 25(6):843-54.
ncbi Jonathan M. Labriola, Akash Pandhare, Michaela Jansen, Michael P. Blanton, Pierre-Jean Corringer, John E. Baenziger (2013). Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment. J Biol Chem 288(16):11294-303.
ncbi Akash Pandhare, Ayman K. Hamouda, Brandon Staggs, Shaili Aggarwal, Phaneendra K. Duddempudi, John R. Lever, David J. Lapinsky, Michaela Jansen, Jonathan B. Cohen, Michael P. Blanton (2012). Bupropion Binds to Two Sites in the Torpedo Nicotinic Acetylcholine Receptor Transmembrane Domain: A Photoaffinity Labeling Study with the Bupropion Analogue [125I]-SADU-3-72. Biochemistry. 51(12):2425-35.
ncbi Raman Goyal, Ahmed Abdullah Salahudeen, Michaela Jansen (2011). Engineering a Prokaryotic Cys-loop Receptor with a Third Functional Domain. J Biol Chem. 286(40):34635-42.
ncbi A. Bauman, M. Piel, S. Höhnemann, A. Krauss, Michaela Jansen, C. Solbach, G. Dannhardt,b and F. Rösch (2010). Synthesis, labelling and evaluation of hydantoin‐substituted indole carboxylic acids as potential ligands for positron emission tomography imaging of the glycine binding site of the N‐methyl‐D‐aspartate receptor. J Label Compd Radiopharm. 54(10):645-656.
ncbi Moez Bali, Michaela Jansen and Myles H. Akabas (2009). GABA-Induced Intersubunit Conformational Movement in the GABAA Receptor α1M1-β2M3 Transmembrane Subunit Interface: Experimental Basis for Homology Modeling of an Intravenous Anesthetic Binding Site. J Neurosci.29 (10) 3083-3092.
ncbi Roger Ernest Wiltfong and Michaela Jansen (2009). Probing Protein Packing Surrounding the Residues in and Flanking the Nicotinic Acetylcholine Receptor M2M3 Loop. J Neuroscience. 29(6):1626 –1635.
ncbi Michaela Jansen, Holger Rabe, Axelle Strehle, Sandra Dieler, Fabian Debus, Gerd Dannhardt, Myles H. Akabas, and Hartmut Luddens (2007). Synthesis of GABAA Receptor Agonists and Evaluation of their α-Subunit Selectivity and Orientation in the GABA Binding Site. J Med Chem. 51(15):4430-48
ncbi Rongbao Zhao, Andong Qiu, Eugenia Tsai, Michaela Jansen, Myles H. Akabas, and I. David Goldman (2008). The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier. Mol Pharmacol. 74(3):854-62.
ncbi Michaela Jansen , Moez Bali , and Myles H. Akabas (2008). Modular Design of Cys-loop Ligand-gated Ion Channels: Functional 5-HT 3 and GABA 1 Receptors Lacking the Large Cytoplasmic M3M4 Loop. J. Gen. Physiol. 131: 137–146.
ncbi Andong Qiu, Sang Hee Min, Michaela Jansen, Usha Malhotra, Eugenia Tsai, Diane C. Cabelof, Larry H. Matherly, Rongbao Zhao, Myles H. Akabas, and I. David Goldman (2007). Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. Am J Physiol Cell Physiol. 293: C1669–C1678.
ncbi Andong Qiu, Michaela Jansen, Antoinette Sakaris, Sang Hee Min, Shrikanta Chattopadhyay, Eugenia Tsai, Claudio Sandoval, Rongbao Zhao, Myles H. Akabas, and I. David Goldman (2006). Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption. Cell. 127(5):917-28.
ncbi Michaela Jansen and Myles H. Akabas (2006). State-Dependent Cross-Linking of the M2 and M3 Segments: Functional Basis for the Alignment of GABAA and Acetylcholine Receptor M3 Segments. J Neurosci. 26(17):4492– 4499.
ncbi David C. Reeves, Michaela Jansen, Moez Bali, Thomas Lemster, and Myles H. Akabas (2005). A Role for the 1 – 2 Loop in the Gating of 5-HT3 Receptors. J Neurosci. 25(41):9358 –9366. 

Complete list of publications.

JansenLab 2019 Bounce

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Michaela Jansen

michaela.jansen@ttuhsc.edu