Dr. Li obtained extensive training in genomics and bioinformatics. His previous genetic research has led to the identification of dozens of disease-associated genes. Many of the findings have been applied to translational research in academia and industry. His recent work focuses on developing novel methods and bioinformatics tools for analyzing genomic sequencing data and applying them to various diseases and health conditions.
Research Interests:
Genomics; Bioinformatics; Genomic medicine
Selected Publications:
Chen X, Kost J, Sulovari A, Wong N, Liang WS, Cao J, Li D*. A virome-wide clonal integration analysis platform for discovering cancer viral etiology. Genome Research. 2019 May;29(5):819-830. PMID: 30872350. PMCID: PMC6499315. (* corresponding author).
Chen X, Li D*. ERVcaller: Identifying polymorphic endogenous retrovirus and other transposable element insertions using whole-genome sequencing data. Bioinformatics. 2019 Oct 15;35(20):3913-3922. PMID: 30895294. (* corresponding author).
Liu G, Chen X, Luan Y, Li D*. VirusPredictor: XGBoost-based software to predict virus-related sequences in human data. (* corresponding author). Bioinformatics. 2024 Mar 29;40(4):btae192. PMID: 38597887. PMCID: PMC11052659.
Chen X, Kost J, Li D*. Comprehensive comparative analysis of methods and software for identifying viral integrations. Briefings in Bioinformatics. 2019 Nov 27;20(6):2088-2097. PMID: 30102374. (* corresponding author).
Chen X, Li D*. Sequencing facility and DNA source associated patterns of virus-mappable reads in whole-genome sequencing data. Genomics. 2021 Jan;113(1 Pt 2):1189-1198. PMID: 33301893. PMCID: PMC7856238. (* corresponding author).
Sulovari A, Li D*. VIpower: Simulation-based tool for estimating power of viral integration detection via high-throughput sequencing. Genomics. 2020 Jan 10;112(1):207-211. PMID: 30710609. (* corresponding author).
Li D*. Mosaic Chromosomal Alterations/Somatic Copy Number Variations: A New Frontier in Genetic Association Studies of Complex Diseases. Biological Psychiatry. 2025 Jan 15;97(2):104-106. PMID: 39663014. PMCID: PMC11795703. (* corresponding author). Invited.
Obraitis D, Li D*. Blood virome research in myalgic encephalomyelitis/chronic fatigue syndrome: challenges and opportunities. Current Opinion in Virology. 2024 Sep-Dec:68-69:101437. PMID: 39537445. PMCID: PMC11795702. (* corresponding author). Invited.
Complete List of Published Work in MyBibliography:
www.ncbi.nlm.nih.gov/myncbi/dawei.li.1/bibliography/public
Interests
- Addiction
- Cancer
- Genomic/proteomic analysis